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Titolo:
Axonal injury is accentuated in the caudal corpus callosum of head-injuredpatients
Autore:
Leclercq, PD; McKenzie, JE; Graham, DI; Gentleman, SM;
Indirizzi:
Univ London Imperial Coll Sci Technol & Med, Sch Med, Div Neurosci & Psychol Med, Dept Neuroinflammat, London W6 8RP, England Univ London Imperial Coll Sci Technol & Med London England W6 8RP ngland Univ Glasgow, So Gen Hosp, Inst Neurol Sci, Dept Neuropathol, Glasgow, Lanark, Scotland Univ Glasgow Glasgow Lanark Scotland ropathol, Glasgow, Lanark, Scotland
Titolo Testata:
JOURNAL OF NEUROTRAUMA
fascicolo: 1, volume: 18, anno: 2001,
pagine: 1 - 9
SICI:
0897-7151(200101)18:1<1:AIIAIT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; TRAUMATIC BRAIN INJURY; INTRACRANIAL-PRESSURE; WHITE-MATTER; BETA-APP; DAMAGE; ACCUMULATION; RAT; DIAGNOSIS; MARKER;
Keywords:
amyloid precursor protein; corpus callosum; diffuse axonal injury; head injury; image analysis; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Gentleman, SM Univ London Imperial Coll Sci Technol & Med, Sch Med, Div Neurosci & Psychol Med, Dept Neuroinflammat, Charing Cross Campus,St DunstansRd, London W68RP, England Univ London Imperial Coll Sci Technol & Med Charing Cross Campus,St Dunstans Rd London England W6 8RP
Citazione:
P.D. Leclercq et al., "Axonal injury is accentuated in the caudal corpus callosum of head-injuredpatients", J NEUROTRAU, 18(1), 2001, pp. 1-9

Abstract

Amyloid precursor protein (APP) accumulation is a sensitive marker for theaxonal damage that is commonly seen in the brain as the result of head injury. This form of damage is particularly associated with midline structuressuch as the corpus callosum, although it is not clear whether some areas are more susceptible than others. The aim of this study was to determine if there was a differential distribution of axonal injury throughout the corpus callosum after head injury in an unselected group of cases. Coronal tissue sections from eight cases were taken at different levels through the corpus callosum, including the genu, body, and splenium, The sections were immunostained with an antibody to APP, and the amount of axonal damage at the different levels was quantified using computer image analysis to build up a rostro-caudal profile for each case. The profiles revealed a significantly higher APP load in caudal parts of the corpus callosum, This supports previous non-quantitative reports in the literature and has important implications in terms of choosing where tissue should be sampled to maximize the chance of detecting axonal injury post mortem.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:35:31