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Titolo:
Expression of Fos immunoreactivity in some catecholaminergic brainstem neurons in rats following high-altitude exposure
Autore:
Kaur, C; You, Y; Singh, J; Peng, CM; Ling, EA;
Indirizzi:
Natl Univ Singapore, Fac Med, Dept Anat, Singapore 117597, Singapore Natl Univ Singapore Singapore Singapore 117597 ngapore 117597, Singapore Singapore Technol Med Serv Pte Ltd, Aeromed Ctr, Singapore, Singapore Singapore Technol Med Serv Pte Ltd Singapore Singapore apore, Singapore
Titolo Testata:
JOURNAL OF NEUROSCIENCE RESEARCH
fascicolo: 1, volume: 63, anno: 2001,
pagine: 54 - 63
SICI:
0360-4012(20010101)63:1<54:EOFIIS>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MOUNTAIN-SICKNESS; LONG-TERM HYPOXIA; SYMPATHETIC ACTIVATION; VENTROLATERAL MEDULLA; TYROSINE-HYDROXYLASE; PULMONARY-EDEMA; AREA POSTREMA; CELL COLUMN; SPINAL-CORD; C-FOS;
Keywords:
high altitude; hypoxia; c-fos; nucleus tractus solitarius; ventrolateral medulla; area postrema;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Kaur, C Natl Univ Singapore, Fac Med, Dept Anat, Blk MD10,4 Med Dr, Singapore 117597, Singapore Natl Univ Singapore Blk MD10,4 Med Dr Singapore Singapore 117597
Citazione:
C. Kaur et al., "Expression of Fos immunoreactivity in some catecholaminergic brainstem neurons in rats following high-altitude exposure", J NEUROSC R, 63(1), 2001, pp. 54-63

Abstract

This study examined the response of neurons of the cardiorespiratory centers, i.e., the nucleus tractus solitarius and the ventrolateral medulla as well as the area postrema in adult and postnatal rats subjected to high-altitude exposure at 4,000 m and 8,000 m. In adult control rats, sporadic Fos-positive neurons were detected in the above-mentioned areas. On exposure to 4,000 m altitude, the number of Fos-positive neurons was noticeably increased. At 8,000 m, the incidence of labeled cells was markedly increased, withmany of them doubly labeled for tyrosine hydroxylase. In postnatal rats, Fos expression was not detected in these areas in either control rats or rats exposed to 4,000 m altitude. Fos-positive cells, however, were observed in the these areas in postnatal rats exposed to 8,000 m. In the latter, tyrosine hydroxylase labeling was observed in some Fos-positive cells in the nucleus tractus solitarius and ventrolateral medulla. in rats killed at 24 hrafter exposure to high altitude, Fos expression in both the adult and the postnatal rats was comparable to that in their corresponding control rats. Present results suggest that Fos expression in various brainstem areas was induced by reduced oxygen tension in the ambient air at high altitude. Double labeling of some Fos-positive neurons with tyrosine hydroxylase indicates an increased sympathetic activation, which may be involved in the mediation of cardiorespiratory responses to hypoxia. This, however, was less evident in the postnatal animals. It is possible that the peripheral chemoreceptors or the regulation of autonomic functions is not fully developed in thisage group. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:35:59