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Titolo:
AMPA receptor activation leads to neurite retraction in tangentially migrating neurons in the intermediate zone of the embryonic rat neocortex
Autore:
Poluch, S; Drian, MJ; Durand, M; Astier, C; Benyamin, Y; Konig, N;
Indirizzi:
Univ Montpellier, INSERM, U336, EPHE Biol Cellulaire Quantitat, F-34095 Montpellier, France Univ Montpellier Montpellier France F-34095 F-34095 Montpellier, France Univ Montpellier, CNRS, UMR 5539, EPHE Motilite Cellulaire, F-34095 Montpellier, France Univ Montpellier Montpellier France F-34095 F-34095 Montpellier, France
Titolo Testata:
JOURNAL OF NEUROSCIENCE RESEARCH
fascicolo: 1, volume: 63, anno: 2001,
pagine: 35 - 44
SICI:
0360-4012(20010101)63:1<35:ARALTN>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICROTUBULE ASSEMBLY INVITRO; NMDA RECEPTORS; POSTNATAL-DEVELOPMENT; GLUTAMATE RECEPTORS; HORMONE NEURONS; POLYSIALIC ACID; CELLS; GROWTH; GABA; CALCIUM;
Keywords:
non-radial migration; development; immunocytochemistry; cobalt labeling; calcium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Konig, N Univ Montpellier, INSERM, U336, EPHE Biol Cellulaire Quantitat, 2-CC 106,Pl E Bataillon, F-34095 Montpellier, France Univ Montpellier 2-CC 106,Pl E Bataillon Montpellier France F-34095
Citazione:
S. Poluch et al., "AMPA receptor activation leads to neurite retraction in tangentially migrating neurons in the intermediate zone of the embryonic rat neocortex", J NEUROSC R, 63(1), 2001, pp. 35-44

Abstract

In rat (Konig et al, [1998] 28th Annual Meeting of the Society of Neuroscience, Los Angeles. 24:314.6) and mouse (Metin et al, [2000] J. Neurosci. 20:696-708), neurons migrating tangentially in the intermediate zone (IZ) of the neocortical anlage express functional AMPA receptors permeable to calcium. The role of these receptors is as yet unknown. We exposed organotypic cultures of rat telencephalon (embryonic day 15) to AMPA receptor agonists or antagonists, and analyzed the effects of these treatments on cells in theIZ labeled with antibodies against the isoforms a, b and c of microtubule associated protein 2 (MAP2) and the polysialylated neural cell adhesion molecule (PSA-NCAM). The presence of functional AMPA receptors permeable to calcium was checked by cobalt-loading. After exposure to AMPA alone for at least 6 hr, we observed a significant increase in the number of rounded, MAP2positive cells in the IZ close to the migratory front. When AMPA was combined with cyclothiazide, the increase was already significant after 3 hr. These effects were dose-dependent and could be partially or totally blocked by DNQX or GYKI 53655 respectively, that suggests that they are mediated by AMPA receptors. Paracrine AMPA receptor activation might participate, together with other signals, in guiding the migratory stream, or provide stop signals for migrating cells. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 01:41:56