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Titolo:
Prepulse inhibition deficits and perseverative motor patterns in dopamine transporter knock-out mice: Differential effects of D1 and D2 receptor antagonists
Autore:
Ralph, RJ; Paulus, MP; Fumagalli, F; Caron, MG; Geyer, MA;
Indirizzi:
Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA Univ Calif SanDiego La Jolla CA USA 92093 ychiat, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA Univ Calif SanDiego La Jolla CA USA 92093 urosci, La Jolla, CA 92093 USA Univ Milan, Inst Pharmacol Sci, Ctr Neuropharmacol, I-20133 Milan, Italy Univ Milan Milan Italy I-20133 Ctr Neuropharmacol, I-20133 Milan, Italy Duke Univ, Med Ctr, Howard Hughes Med Inst, Dept Cell Biol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Inst, Dept Cell Biol, Durham, NC 27710 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 1, volume: 21, anno: 2001,
pagine: 305 - 313
SICI:
0270-6474(20010101)21:1<305:PIDAPM>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOURETTES-SYNDROME; STARTLE; RATS; AMPHETAMINE; LOCOMOTOR; BEHAVIOR; HABITUATION; HYPERLOCOMOTION; SCHIZOPHRENIA; APOMORPHINE;
Keywords:
dopamine; prepulse inhibition; mice; behavior; dopamine transporter; locomotor activity; perseveration; D1 receptor; D2 receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Geyer, MA Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA UnivCalif San Diego La Jolla CA USA 92093 Jolla, CA 92093 USA
Citazione:
R.J. Ralph et al., "Prepulse inhibition deficits and perseverative motor patterns in dopamine transporter knock-out mice: Differential effects of D1 and D2 receptor antagonists", J NEUROSC, 21(1), 2001, pp. 305-313

Abstract

Dopamine is known to regulate several behavioral phenomena, including sensorimotor gating and aspects of motor activity. The roles of dopamine D1 andD2 receptors in these behaviors have been documented in the rat literature, but few reports exist on their role in mice. We used dopamine transporter(DAT) (-/-) mice to examine the behavioral consequences of a chronically hyperdopaminergic state, challenging them with the preferential dopamine D2 receptor antagonist raclopride and D1 receptor antagonist SCH23390. At baseline, DAT (-/-) mice exhibited deficient sensorimotor gating as measured byprepulse inhibition (PPI) of the startle response, exhibited nonfocal perseverative patterns of locomotion, and were hyperactive in a novel environment. Pretreatment with raclopride significantly increased PPI in the DAT (-/-) mice, whereas SCH23390 had no significant effect. Blockade of D2 receptors did not affect the predominantly straight patterns of motor behavior produced by the DAT (-/-) mice, but antagonism of D1 receptors significantly attenuated the perseverative patterns, producing more of a meandering behavior seen in the DAT (+/+) control mice. Both D1 and D2 receptor antagonists decreased the hyperactivity seen in the DAT (-/-) mice. These findings support the role of the D2, but not the D1, receptor in the modulation of PPI in mice. Furthermore, D1 receptor activation appears to be the critical substrate for the expression of perseverative patterns of motor behavior, whereas both D1 and D2 receptors appear to regulate the amount of motor activity.

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Documento generato il 07/04/20 alle ore 22:37:30