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Titolo:
Enhanced cortical extracellular levels of cholecystokinin-like material ina model of anticipation of social defeat in the rat
Autore:
Becker, C; Thiebot, MH; Touitou, Y; Hamon, M; Cesselin, F; Benoliel, JJ;
Indirizzi:
Fac Med Pitie Salpetriere, INSERM, U288, F-75634 Paris 13, France Fac Med Pitie Salpetriere Paris France 13 U288, F-75634 Paris 13, France Fac Med Pitie Salpetriere, Serv Biochim Med, F-75634 Paris, France Fac MedPitie Salpetriere Paris France F-75634 ed, F-75634 Paris, France
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 1, volume: 21, anno: 2001,
pagine: 262 - 269
SICI:
0270-6474(20010101)21:1<262:ECELOC>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
YOHIMBINE-INDUCED RELEASE; B RECEPTOR ANTAGONISTS; CENTRAL NERVOUS-SYSTEM; FREELY MOVING RAT; FRONTAL-CORTEX; EXPLORATORY-BEHAVIOR; PANIC DISORDER; BRAIN-REGIONS; SUBSTANCE-P; IN-VIVO;
Keywords:
CCK; in vivo microdialysis; frontal cortex; anticipation of social defeat; anxiolytics; stress; anxiety;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Benoliel, JJ Fac Med Pitie Salpetriere, INSERM, U288, F-75634 Paris 13, France Fac Med Pitie Salpetriere Paris France 13 Paris 13, France
Citazione:
C. Becker et al., "Enhanced cortical extracellular levels of cholecystokinin-like material ina model of anticipation of social defeat in the rat", J NEUROSC, 21(1), 2001, pp. 262-269

Abstract

The involvement of cholecystokinin (CCK) in the mechanisms of stress and/or anxiety was assessed by in vivo microdialysis in rats subjected to a social stress paradigm. During the initial 30 min period of each conditioning session, a male Sprague Dawley rat (intruder) was placed in a protective cage inside the cage of a male Tryon Maze Dull rat (resident), allowing unrestricted visual, olfactory, and auditory contacts but precluding close physical contact between them. During the following 15 min period, both the protective cage and the resident were removed (nondefeated intruders) or only the protective cage was removed allowing the resident to attack the intruder (defeated rats). This procedure was repeated once daily for 4 d. On the fifth day, a guide cannula was implanted into the prefrontal cortex of intruders. During a single 30 min test session, performed 4 d later, intruders were subjected to only the 30 min protected confrontation to the resident. Anxiety-like behavior (immobility, ultrasonic vocalizations, and defensive postures), associated with an increase (approximately +100% above baseline) incortical outflow of CCK-like material (CCKLM), were observed in defeated intruders. Pretreatment with diazepam (5 mg/kg, i.p.), but not buspirone (0.5-2 mg/kg, i.p.), prevented both the anxiety-related behavior and CCKLM overflow. The selective CCK-B receptor antagonist CI-988 (2 mg/kg, i.p.) reduced the anxiety-like behavior without affecting the increase in CCKLM outflow. These data indicate that anticipation of social defeat induces a marked activation of cortical CCKergic neurons associated with anxiety-related behaviors in rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 13:01:34