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Titolo:
The contribution of dendritic Kv3 K+ channels to burst threshold in a sensory neuron
Autore:
Rashid, AJ; Morales, E; Turner, RW; Dunn, RJ;
Indirizzi:
Montreal Gen Hosp, Dept Neurol, Montreal, PQ H3G 1A4, Canada Montreal Gen Hosp Montreal PQ Canada H3G 1A4 Montreal, PQ H3G 1A4, Canada Montreal Gen Hosp, Dept Biol, Montreal, PQ H3G 1A4, Canada Montreal Gen Hosp Montreal PQ Canada H3G 1A4 Montreal, PQ H3G 1A4, Canada Montreal Gen Hosp, Ctr Res Neurosci, Montreal, PQ H3G 1A4, Canada MontrealGen Hosp Montreal PQ Canada H3G 1A4 Montreal, PQ H3G 1A4, Canada Univ Calgary, Neurosci Res Grp, Calgary, AB T2N 4N1, Canada Univ Calgary Calgary AB Canada T2N 4N1 s Grp, Calgary, AB T2N 4N1, Canada
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 1, volume: 21, anno: 2001,
pagine: 125 - 135
SICI:
0270-6474(20010101)21:1<125:TCODKK>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
FISH APTERONOTUS-LEPTORHYNCHUS; HIPPOCAMPAL PYRAMIDAL NEURONS; GATED POTASSIUM CHANNELS; WEAKLY ELECTRIC FISH; LATERAL-LINE LOBE; SUBUNIT KV3.1B; FEATURE-EXTRACTION; GUANYLATE KINASES; MESSENGER-RNA; CNS NEURONS;
Keywords:
potassium channel; Kv3; dendritic spike; action potential; backpropagation; oscillatory discharge; repolarization; DAP; electrosensory;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Dunn, RJ Montreal Gen Hosp, Dept Neurol, 1650 Cedar Ave, Montreal, PQ H3G 1A4, Canada Montreal Gen Hosp 1650 Cedar Ave Montreal PQ Canada H3G 1A4 anada
Citazione:
A.J. Rashid et al., "The contribution of dendritic Kv3 K+ channels to burst threshold in a sensory neuron", J NEUROSC, 21(1), 2001, pp. 125-135

Abstract

Voltage-gated ion channels localized to dendritic membranes can shape signal processing in central neurons. This study describes the distribution andfunctional role of a high voltage-activating K+ channel in the electrosensory lobe (ELL) of an apteronotid weakly electric fish. We identify a homolog of the Kv3.3 K+ channel, AptKv3.3, that exhibits a high density of mRNA expression and immunolabel that is distributed over the entire soma-dendritic axis of ELL pyramidal cells. The kinetics and pharmacology of native K+ channels recorded in pyramidal cell somata and apical dendrites match those of AptKv3.3 channels expressed in a heterologous expression system. The functional role of AptKv3.3 channels was assessed using focal drug ejections in somatic and dendritic regions of an in vitro slice preparation. Local blockade of AptKv3.3 channels slows the repolarization of spikes in pyramidal cell somata as well as spikes backpropagating into apical dendrites. The resulting increase in dendritic spike duration lowers the threshold for a gamma -frequency burst discharge that is driven by inward current associated with backpropagating dendritic spikes. Thus, dendritic AptKv3.3 K+ channels influence the threshold for a form of burst discharge that has an established role in feature extraction of sensory input.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 09:07:30