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Titolo:
Mechanisms of dendritic calcium signaling in fly neurons
Autore:
Oertner, TG; Brotz, TM; Borst, A;
Indirizzi:
Max Planck Soc, Friedrich Miescher Lab, D-72076 Tubingen, Germany Max Planck Soc Tubingen Germany D-72076 r Lab, D-72076 Tubingen, Germany
Titolo Testata:
JOURNAL OF NEUROPHYSIOLOGY
fascicolo: 1, volume: 85, anno: 2001,
pagine: 439 - 447
SICI:
0022-3077(200101)85:1<439:MODCSI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRINSIC ELECTROPHYSIOLOGICAL CHARACTERISTICS; BLOWFLY CALLIPHORA-ERYTHROCEPHALA; MOTION SENSITIVE INTERNEURONS; PLATE TANGENTIAL CELLS; GIANT VERTICAL CELLS; LOBULA PLATE; VISUAL INTERNEURONS; HORIZONTAL CELLS; DIRECTION SELECTIVITY; MEMBRANE-PROPERTIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Oertner, TG Cold Spring Harbor Lab, POB 100,1 Bungtown Rd, Cold Spring Harbor, NY 11724 USA Cold Spring Harbor Lab POB 100,1 Bungtown Rd Cold Spring Harbor NY USA 11724
Citazione:
T.G. Oertner et al., "Mechanisms of dendritic calcium signaling in fly neurons", J NEUROPHYS, 85(1), 2001, pp. 439-447

Abstract

We examined the mechanisms underlying dendritic calcium accumulation in lobula plate tangential cells of the fly visual system using an in vitro preparation of the fly brain. Local visual stimulation evokes a localized calcium signal in the dendrites of these cells in vivo. Here we show that a similar localized calcium accumulation can be elicited in vitro by focal iontophoretic application of the cholinergic agonist carbachol. The calcium signal had at least two sources: first, voltage-dependent calcium channels contributed to the carbachol-induced signal and were concentrated on the dendrite, the soma, and the terminal ramification of the axon. However, the dendritic calcium signal induced by carbachol stimulation was only weakly dependent on membrane depolarization. The most likely explanation for the second, voltage-independent part of the dendritic calcium signal is calcium entry through nicotinic acetylcholine receptors. We found no indication of second-messenger or calcium-mediated calcium release from intracellular stores. Insummary, the characteristic spatiotemporal calcium signals in the dendrites of lobula plate tangential cells can be reproduced in vitro, and result from a combination of voltage- and ligand-gated calcium influx.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 23:06:40