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Titolo:
Anti-a alpha B-crystallin immunoreactivity in inflammatory nervous system diseases
Autore:
Celet, B; Akman-Demir, G; Serdaroglu, P; Yentur, SP; Tasci, B; van Noort, JM; Eraksoy, M; Saruhan-Direskeneli, G;
Indirizzi:
Istanbul Univ, Istanbul Fac Med, Dept Physiol, Istanbul, Turkey Istanbul Univ Istanbul Turkey l Fac Med, Dept Physiol, Istanbul, Turkey Istanbul Univ, Istanbul Fac Med, Dept Neurol, Istanbul, Turkey Istanbul Univ Istanbul Turkey ul Fac Med, Dept Neurol, Istanbul, Turkey TNO Prevent & Hlth, Div Infect Dis & Immunol, Leiden, Netherlands TNO Prevent & Hlth Leiden Netherlands is & Immunol, Leiden, Netherlands
Titolo Testata:
JOURNAL OF NEUROLOGY
fascicolo: 12, volume: 247, anno: 2000,
pagine: 935 - 939
SICI:
0340-5354(200012)247:12<935:AABIII>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEAT-SHOCK-PROTEIN; MULTIPLE-SCLEROSIS; BEHCETS-DISEASE; CANDIDATE AUTOANTIGEN; MYCOBACTERIAL; EXPRESSION; CELLS; INVOLVEMENT; ANTIBODIES; GLIA;
Keywords:
alpha B-crystallin; neuro-Behcet; multiple sclerosis; Guillain-Barre syndrome; antibodies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Saruhan-Direskeneli, G Istanbul Univ, Istanbul Fac Med, Dept Physiol, Istanbul, Turkey Istanbul Univ Istanbul Turkey , Istanbul, Turkey
Citazione:
B. Celet et al., "Anti-a alpha B-crystallin immunoreactivity in inflammatory nervous system diseases", J NEUROL, 247(12), 2000, pp. 935-939

Abstract

alphaB-Crystallin, a small heat shock protein, is an immunodominant antigen with increased tissue expression in demyelination. To investigate the humoral response against alphaB-crystallin, the sera and CSF samples of patients with multiple sclerosis (MS), Guillain-Barre syndrome (GBS), neuro-Behcet's disease (NBD) and other non-inflammatory neurological diseases (NIND) were screened by enzyme-linked immunosorbent assay for anti-alphaB-crystallin IgG and IgM antibodies. Serum and CSF IgG antibody responses to alphaB-crystallin were significantly elevated only in NBD patients (serum IgG, NBD 1.29+/-0.49 vs. NIND 0.95+/-0.39, P=0.01; CSF IgG, NBD 1.22+/-0.64 vs. NIND 0.81+/-0.35, P=0.01). Similarly, high serum IgM antibody titres were also detected in NBD (1.83+/-0.72 vs. 1.16+/-0.49, P=0.0005) and in MS (1.57+/-1.07, P=0.046), whereas elevated CSF IgM responses were observed only in GBS (2.09+/-1.09 vs. 1.41+/-0.7, P=0.007). Humoral responses against alphaB-crystallin are increased in NBD and GBS, which may implicate this central nervous system antigen in the causation and pathogenesis of these inflammatory nervous system disorders.

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Documento generato il 28/09/20 alle ore 17:43:44