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Titolo:
USE AND APPLICATIONS OF PHARMACOGENETICS IN ONCOLOGY AND HEMATOLOGY
Autore:
ALBIN N; MASSADE L; GOUYETTE A;
Indirizzi:
INST GUSTAVE ROUSSY,DEPT PHARMACOGENET & PHARMACOTOXICOL,39 RUE CAMILLE DESMOULINS F-94805 VILLEJUIF FRANCE GRP HOSP PITIE SALPETRIERE,DEPT HEMATOL F-75651 PARIS 13 FRANCE CHU NECKER,INSERM,U75 F-75015 PARIS FRANCE
Titolo Testata:
Bulletin du cancer
fascicolo: 6, volume: 84, anno: 1997,
pagine: 643 - 651
SICI:
0007-4551(1997)84:6<643:UAAOPI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
FRE
Soggetto:
DIHYDROPYRIMIDINE DEHYDROGENASE-DEFICIENCY; ACUTE LYMPHOBLASTIC-LEUKEMIA; METABOLIZING ENZYME-SYSTEMS; GLUTATHIONE S-TRANSFERASES; TRANS-STILBENE OXIDE; EVERY 3 WEEKS; PHASE-I; THIOPURINE METHYLTRANSFERASE; CANCER-PATIENTS; 5-FLUOROURACIL TOXICITY;
Keywords:
PHARMACOGENETICS; GENETIC RISK OF CANCER; ENZYMES OF BIOTRANSFORMATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
79
Recensione:
Indirizzi per estratti:
Citazione:
N. Albin et al., "USE AND APPLICATIONS OF PHARMACOGENETICS IN ONCOLOGY AND HEMATOLOGY", Bulletin du cancer, 84(6), 1997, pp. 643-651

Abstract

Pharmacogenetics could be defined as the study of genetically controlled variations in drug response. Introduction of pharmacogenetics in hematology and oncology has been done recently. With recombinant DNA technology, like restriction analysis of genomic DNA, enzymatic amplification of DNA by the polymerase chain reaction and expression of cDNAs in cell cultures, this research area has been developed during the last 10 years. In hematology and oncology, we can integrate pharmacogenetics in 3 areas. First, the concept of genetic risk of cancer and the study of drug or carcinogen metabolizing enzymes that could modulate this risk, regarding the activity of some specific enzymes; second, the use of pharmacogenetics, related to the toxicity or efficacy of anticancer drugs, allowing the identification of key enzymes involved in thebiotransformation of the drug and the study of molecular aspects involved in regulation of the activity of the enzymes; third, the implication of the study of enzymatic activities in tumoral tissues as compared to non-tumoral tissues. The following differencies between the 2 tissues can be subsequently used to increase the specificity of the anticancer drugs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 03:25:58