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Titolo:
Concordance of dermatitis herpetiformis and celiac disease in monozygous twins
Autore:
Hervonen, K; Karell, K; Holopainen, P; Collin, P; Partanen, J; Reunala, T;
Indirizzi:
Finnish Red Cross & Blood Transfus Serv, Dept Tissue Typing, Helsinki 00310, Finland Finnish Red Cross & Blood Transfus Serv Helsinki Finland 00310, Finland Tampere Univ Hosp, Dept Dermatol, Tampere, Finland Tampere Univ Hosp Tampere Finland Hosp, Dept Dermatol, Tampere, Finland Tampere Univ Hosp, Dept Med, Tampere, Finland Tampere Univ Hosp Tampere Finland Univ Hosp, Dept Med, Tampere, Finland Tampere Univ Hosp, Sch Med, Tampere, Finland Tampere Univ Hosp Tampere Finland Univ Hosp, Sch Med, Tampere, Finland
Titolo Testata:
JOURNAL OF INVESTIGATIVE DERMATOLOGY
fascicolo: 6, volume: 115, anno: 2000,
pagine: 990 - 993
SICI:
0022-202X(200012)115:6<990:CODHAC>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTEN-SENSITIVE ENTEROPATHY; T-CELL RECEPTOR; SUSCEPTIBILITY GENES; SKIN-LESIONS; FREE DIET; HLA-DQ; INHERITANCE; DISCORDANCE; LINKAGE;
Keywords:
genetic mapping; gluten sensitivity; multifactorial disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Partanen, J Finnish Red Cross & Blood Transfus Serv, Dept Tissue Typing, Kivihaantie 7, Helsinki 00310, Finland Finnish Red Cross & Blood Transfus Serv Kivihaantie 7 Helsinki Finland 00310
Citazione:
K. Hervonen et al., "Concordance of dermatitis herpetiformis and celiac disease in monozygous twins", J INVES DER, 115(6), 2000, pp. 990-993

Abstract

Celiac disease can be defined as the classical manifestation of gluten sensitivity, which primarily affects the small intestine. Gluten sensitivity has also a skin manifestation, i.e., dermatitis herpetiformis, Both diseaseshave a strong genetic association with HLA DQ on chromosome 6, In this study we tried to estimate how much different clinical expressions of gluten sensitivity are determined by genetic factors, and hence how feasible they are for genetic mapping; therefore, we studied all six monozygous twin pairsfound among 1292 prospectively collected patients of dermatitis herpetiformis in Finland, Three of the six twin pairs were concordant for dermatitis herpetiformis and for simultaneous enteropathy, celiac disease. Two other twin pairs were partially discordant, one of each pair had dermatitis herpetiformis and celiac disease, whereas the other had solely the gut manifestation of gluten sensitivity, i.e,, celiac disease. Only one pair was found tobe discordant for gluten sensitivity, All the pairs had typical risk alleles for gluten sensitivity, i.e., either HLA DQ2 or DQ8, These results demonstrate that the genetic component in gluten sensitivity as broadly defined is very strong (5/6 concordant), Genetically identical individuals can haveclearly distinguished phenotypes, either dermatitis herpetiformis or celiac disease, suggesting that environmental factors determine the exact phenotype of this multifactorial disease. These findings are of importance in genetic linkage analyses, which focus to only certain phenotypic properties ofa complex trait.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:28:15