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Titolo:
Clinical study of cefpirome sulphate in obstetric and gynaecological infections
Autore:
Sagawa, T; Fujino, T; Sakuragi, N; Kishida, T; Yamada, H; Fujimoto, S;
Indirizzi:
Hokkaido Univ, Sch Med, Dept Obstet & Gynaecol, Kita Ku, Sapporo, Hokkaido0608638, Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 poro, Hokkaido0608638, Japan
Titolo Testata:
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
fascicolo: 6, volume: 28, anno: 2000,
pagine: 288 - 299
SICI:
0300-0605(200011/12)28:6<288:CSOCSI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
INVITRO ACTIVITY; CEPHALOSPORIN; HR-810;
Keywords:
cefpirome sulphate; cephalosporin; antibacterials; obstetric and gynaecological infections; Enterococcus faecalis; bacteroides species;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
6
Recensione:
Indirizzi per estratti:
Indirizzo: Sagawa, T Hokkaido Univ, Sch Med, Dept Obstet & Gynaecol, Kita Ku, Kita 15Jo Nishi 7 chome, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ Kita 15 Jo Nishi 7 chome Sapporo Hokkaido Japan 0608638
Citazione:
T. Sagawa et al., "Clinical study of cefpirome sulphate in obstetric and gynaecological infections", J INT MED R, 28(6), 2000, pp. 288-299

Abstract

Cefpirome sulphate is a fourth-generation cephem antibiotic, which has a broad spectrum of antibacterial activity against Gram-positive and -negativebacteria, and is highly stable to p-lactamase. Cefpirome sulphate was administered to 166 patients with obstetric or gynaecological infections, and its clinical and antibacterial effect was evaluable in 139. Excluding seven patients who violated the study protocol by receiving concomitant drugs, the safety of cefpirome sulphate was assessed in 159 patients. In the 139 patients in whom efficacy was evaluated, the improvement rate was 80.6% (112/139) and the eradication rate 72.6% (45/62). The eradication rate for bacteria isolated from the patients at the start of the study was 84.7% (111/131). No resistance to cefpirome sulphate was observed in Enterococcus faecalisor Bacteroides species. Systemic erythema and nausea each occurred in one patient, and nine patients showed abnormal hepatic function test results. These results suggest that cefpirome sulphate is effective in the treatment of obstetric and gynaecological infections and has a good side-effect profile.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:06:08