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Titolo:
Antibody production in mice deficient for complement receptors 1 and 2 canbe induced by IgG/Ag and IgE/Ag, but not IgM/Ag complexes
Autore:
Applequist, SE; Dahlstrom, J; Jiang, N; Molina, H; Heyman, B;
Indirizzi:
Uppsala Univ, Rudbeck Lab, Dept Genet & Pathol, SE-75185 Uppsala, Sweden Uppsala Univ Uppsala Sweden SE-75185 & Pathol, SE-75185 Uppsala, Sweden Washington Univ, Sch Med, Dept Med, Div Rheumatol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 v Rheumatol, St Louis, MO 63110 USA
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 5, volume: 165, anno: 2000,
pagine: 2398 - 2403
SICI:
0022-1767(20000901)165:5<2398:APIMDF>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMORAL IMMUNE-RESPONSE; T-DEPENDENT ANTIGEN; B-CELL RESPONSE; MEDIATED ENHANCEMENT; IN-VIVO; MONOCLONAL-ANTIBODY; HAPTEN ANTIBODIES; CLASSICAL PATHWAY; IMMUNOGLOBULIN-E; DENDRITIC CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Heyman, B Uppsala Univ, Rudbeck Lab, Dept Genet & Pathol, SE-75185 Uppsala, Sweden Uppsala Univ Uppsala Sweden SE-75185 SE-75185 Uppsala, Sweden
Citazione:
S.E. Applequist et al., "Antibody production in mice deficient for complement receptors 1 and 2 canbe induced by IgG/Ag and IgE/Ag, but not IgM/Ag complexes", J IMMUNOL, 165(5), 2000, pp. 2398-2403

Abstract

Deficiencies in C factors C2, C3, or C4 as well as lack of C receptors 1 and 2 (CR1/2) lead to impaired Ab production. Classical pathway activation plays a major role, as mice deficient in factor B, a key factor in the alternative pathway, have normal Ab production Abs in complex with their specific Ag are known to feedback regulate the Ab response, and enhanced responsesare initiated by IgM, IgE, and IgG, IgM acts via the C system, whereas IgEand Ige can operate independently of C via Fc receptors, Here we have investigated whether these isotypes are able to enhance Ab responses in mice lacking CR1/2, SRBC-specific IgM, administered with SRBC, does not enhance Abresponses in these animals. In contrast, 2,4,6-trinitrophenyl-specific IgEand IgG2a, administered with BSA-2,4,6-trinitrophenyl, induce potent Ab responses in CR1/2-deficient mice. Additionally, BSA administered with CFA oralum induced strong Ab responses in the absence of CR1/2, These results indicate that CR1/2 is needed to promote IgM-mediated induction of primary Abresponses, The data also show that the need for CR1/2 can be circumvented by Abs typical of a secondary immune response forming complexes with Ag or by conventional adjuvants, presumably mimicking physiological inflammatory reactions.

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Documento generato il 26/11/20 alle ore 08:12:07