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Titolo:
Anti-CD69 autoantibodies cross-react with low density lipoprotein receptor-related protein 2 in systemic autoimmune diseases
Autore:
Yu, XH; Matsui, T; Otsuka, M; Sekine, T; Yamamoto, K; Nishioka, K; Kato, T;
Indirizzi:
St Marianna Univ, Sch Med, Inst Med Sci, Rheumatol Immunol & Genet Program,Miyamae Ku, Kanagawa 2168512, Japan St Marianna Univ Kanagawa Japan 2168512 amae Ku, Kanagawa 2168512, Japan Univ Tokyo, Grad Sch Med, Dept Allergy & Rheumatol, Tokyo, Japan Univ Tokyo Tokyo Japan Sch Med, Dept Allergy & Rheumatol, Tokyo, Japan Mitsubishi Kagaku Bioclin Labs Inc, Tokyo, Japan Mitsubishi Kagaku BioclinLabs Inc Tokyo Japan n Labs Inc, Tokyo, Japan
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 2, volume: 166, anno: 2001,
pagine: 1360 - 1369
SICI:
0022-1767(20010115)166:2<1360:AACWLD>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATION ANTIGEN CD69; T-CELL ACTIVATION; C-TYPE LECTIN; LUPUS-ERYTHEMATOSUS; RHEUMATOID-ARTHRITIS; HEYMANN NEPHRITIS; FUNCTIONAL-CHARACTERIZATION; TRANSCRIPTIONAL REGULATION; COSTIMULATORY MOLECULES; HUMAN-LYMPHOCYTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Kato, T St Marianna Univ, Sch Med, Inst Med Sci, Rheumatol Immunol & GenetProgram,Miyamae Ku, 2-16-1 Sugao, Kanagawa 2168512, Japan St Marianna Univ2-16-1 Sugao Kanagawa Japan 2168512 68512, Japan
Citazione:
X.H. Yu et al., "Anti-CD69 autoantibodies cross-react with low density lipoprotein receptor-related protein 2 in systemic autoimmune diseases", J IMMUNOL, 166(2), 2001, pp. 1360-1369

Abstract

We investigated whether autoantibodies to CD69, one of the earliest markers of lymphocyte activation, exist in the sera of patients with systemic autoimmune disease. Serum samples were obtained from patients with rheumatoid arthritis (RA), systemic lupus erythematosus, and Behcet's disease, and were tested for the presence of anti-CD69 autoantibodies by ELISA and Western blotting using rCD69 fusion proteins. IgG-type autoantibodies to CD69 were detected in the sera of 38.3% of the PA patients, 14.5% of the systemic lupus erythematosus patients, and 4.0% of the patients with Behcet's disease. Among those with RA, the anti-CD69 autoantibody-positive patients had a higher serum level of rheumatoid factors and a more accelerated erythrocyte sedimentation rate than the anti-CD69 autoantibody-negative patients. Further, the predominant epitope on the CD69 molecule to which most of the anti-CD69 autoantibody-positive serum samples exclusively reacted, was mapped at the C terminus of CD69. Of interest, this epitope is homologous to a stretchof amino acids in the protein sequence of low-density lipoprotein receptor-related protein 2 (LRP2), which is a receptor for multiple ligands including beta -very low density lipoprotein and is also an autoantigen responsible for Heymann nephritis in rats. The anti-CD69 autoantibody cross-reacted to LRP2 through the homologous amino acid sequence. To our knowledge, this is the first evidence of the existence of anti-CD69 autoantibodies. This autoantibody may modulate the function of CD69- and LRP2-expressing cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:18:45