Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Complete regression of established spontaneous mammary carcinoma and the therapeutic prevention of genetically programmed neoplastic transition by IL-12/pulse IL-2: Induction of local T cell infiltration, Fas/Fas ligand geneexpression, and mammary epithelial apoptosis
Autore:
Wigginton, JM; Park, JW; Gruys, ME; Young, HA; Jorcyk, CL; Back, TC; Brunda, MJ; Strieter, RM; Ward, J; Green, JE; Wiltrout, RH;
Indirizzi:
NCI, Expt Immunol Lab, Div Basic Sci, Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA NCI Frederick MD USA 21702 ck Canc Res & Dev Ctr, Frederick, MD 21702 USA NCI, Pediat Oncol Branch, Div Clin Sci, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 ol Branch, Div Clin Sci, Bethesda, MD 20892 USA NCI, Chemoprevent Lab, Div Basic Sci, Bethesda, MD 20892 USA NCI BethesdaMD USA 20892 vent Lab, Div Basic Sci, Bethesda, MD 20892 USA Sci Applicat Int Corp, Intramural Res Support Program, Frederick, MD 21702USA Sci Applicat Int Corp Frederick MD USA 21702 gram, Frederick, MD 21702USA Hoffmann La Roche Inc, Dept Oncol, Nutley, NJ 07110 USA Hoffmann La Roche Inc Nutley NJ USA 07110 ept Oncol, Nutley, NJ 07110 USA Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 nternal Med, Ann Arbor, MI 48109 USA NCI, Vet & Tumor Pathol Sect, Off Lab Anim Sci, Div Basic Sci,Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA NCI Frederick MD USA 21702 ck Canc Res & Dev Ctr, Frederick, MD 21702 USA
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 2, volume: 166, anno: 2001,
pagine: 1156 - 1168
SICI:
0022-1767(20010115)166:2<1156:CROESM>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; INDUCIBLE PROTEIN-10 IP-10; ANTIGEN-TRANSGENIC MICE; FAS LIGAND; MEDIATED CYTOTOXICITY; STIMULATORY FACTOR; IN-VIVO; ANTITUMOR-ACTIVITY; TUMOR-REGRESSION; GAMMA PRODUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Wiltrout, RH NCI, Expt Immunol Lab, Div Basic Sci, Frederick Canc Res & Dev Ctr, Bldg 560,Room 31-93, Frederick, MD 21702 USA NCI Bldg 560,Room 31-93Frederick MD USA 21702 , MD 21702 USA
Citazione:
J.M. Wigginton et al., "Complete regression of established spontaneous mammary carcinoma and the therapeutic prevention of genetically programmed neoplastic transition by IL-12/pulse IL-2: Induction of local T cell infiltration, Fas/Fas ligand geneexpression, and mammary epithelial apoptosis", J IMMUNOL, 166(2), 2001, pp. 1156-1168

Abstract

Using a novel transgenic mouse model of spontaneous mammary carcinoma, we show here that the IL-12/pulse IL-2 combination can induce rapid and complete regression of well-established autochthonous tumor in a setting where the host immune system has been conditioned by the full dynamic process of neoplastic progression and tumorigenesis. Further, this regimen inhibits neovascularization of established mammary tumors, and does so in conjunction with potent local induction of genes encoding the IFN-gamma- and TNF-alpha -inducible antiangiogenic chemokines IFN-inducible protein 10 and monokine induced by IFN-gamma. In contrast to untreated juvenile C3(1)TAg mice in which histologically normal mammary epithelium predictably undergoes progressive hyperplasia, atypical changes, and ultimately transition to overt carcinoma, the current studies also demonstrate a unique preventative therapeutic role for IL-12/pulse IL-2. In juvenile mice, early administration of IL-12/pulse IL-2 markedly limits the expected genetically programmed neoplastic transition within the mammary epithelium and does so in conjunction with enhancement of constitutive Fas and pronounced induction of local Fas ligand gene expression, T cell infiltration, and induction of apoptosis within the mammary epithelium. These events occur in the absence of a durable Ag-specific memory response. Thus, this novel model system demonstrates that the potent therapeutic activity of the IL-12/pulse IL-2 combination rapidly engages potent apoptotic and antiangiogenic mechanisms that remain active duringthe delivery of IL-12/pulse IL-2. The results also demonstrate that these mechanisms are active against established tumor as well as developing preneoplastic lesions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 12:50:14