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Titolo:
The role of viral load determination for the management of human immunodeficiency virus, hepatitis B virus and hepatitis C virus infection
Autore:
Berger, A; Preiser, W; Doerr, HW;
Indirizzi:
Univ Kliniken Frankfurt, Zentrum Hyg, Inst Med Virol, D-60596 Frankfurt, Germany Univ Kliniken Frankfurt Frankfurt Germany D-60596 596 Frankfurt, Germany
Titolo Testata:
JOURNAL OF CLINICAL VIROLOGY
fascicolo: 1-2, volume: 20, anno: 2001,
pagine: 23 - 30
SICI:
1386-6532(200101)20:1-2<23:TROVLD>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOTHER-TO-INFANT; PERINATAL TRANSMISSION; VERTICAL TRANSMISSION; ZIDOVUDINE TREATMENT; DISEASE PROGRESSION; TYPE-1; RNA; HIV-1; INDIVIDUALS; CHILDREN;
Keywords:
HBV; HCV; HIV; PCR; quantification; nucleic acid;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Berger, A Univ Kliniken Frankfurt, Zentrum Hyg, Inst Med Virol, Paul Ehrlich Str 40,D-60596 Frankfurt, Germany Univ Kliniken Frankfurt Paul Ehrlich Str 40 Frankfurt Germany D-60596
Citazione:
A. Berger et al., "The role of viral load determination for the management of human immunodeficiency virus, hepatitis B virus and hepatitis C virus infection", J CLIN VIRO, 20(1-2), 2001, pp. 23-30

Abstract

During the last 5 years, considerable scientific and financial efforts have been made in the development of quantitative nucleic acid detection technology. For detection of human immunodeficiency virus (HIV), quantitative culture is time consuming, cumbersome and requires appropriate laboratory safety equipment. Quantitative determination of p24 antigen by enzyme immunoassay is of limited value due to its relatively poor sensitivity. Therefore, quantitative determination of viral load using nucleic acid amplification techniques is the most accurate, prognostic marker for HIV type 1 infection,independently of the CD4+ cell count. Hepatitis B virus (HBV) is not cultivable in vitro. Serological assays allow an accurate diagnosis and follow-up of acute or chronic infection. Quantification of HBV DNA is used for the monitoring of antiviral therapy, determination of infectivity and for resolution of unclear serological profiles, e.g. isolated anti-HBc reactivity, as well as for patients in which HBV mutants are suspected. Hepatitis C virus (HCV) can only be detected by molecular based assays because no cell culture system, which permits a reliable isolation of clinical specimens, is currently available. Furthermore, early diagnosis and follow-up of infection cannot be achieved with antibody serology. The prognostic relevance of quantitative HCV RNA determination is of limited value for the long-term prognosis of chronic hepatitis C. However, viral load may predict the outcome of antiviral therapy. Genetic diversity is another challenge for HCV RNA quantification. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:06:56