Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Improvement in mood and fatigue after dehydroepiandrosterone replacement in Addison's disease in a randomized, double blind trial
Autore:
Hunt, PJ; Gurnell, EM; Huppert, FA; Richards, C; Prevost, AT; Wass, JAH; Herbert, J; Chatterjee, VKK;
Indirizzi:
Univ Cambridge, Addenbrookes Hosp, Dept Med, Cambridge CB2 2QQ, England Univ Cambridge Cambridge England CB2 2QQ Med, Cambridge CB2 2QQ, England Univ Cambridge, Addenbrookes Hosp, Dept Psychiat, Cambridge CB2 2QQ, England Univ Cambridge Cambridge England CB2 2QQ iat, Cambridge CB2 2QQ, England Univ Cambridge, Addenbrookes Hosp, Dept Community Med, Cambridge CB2 2QQ, England Univ Cambridge Cambridge England CB2 2QQ Med, Cambridge CB2 2QQ, England Univ Cambridge, Addenbrookes Hosp, Dept Anat, Cambridge CB2 2QQ, England Univ Cambridge Cambridge England CB2 2QQ nat, Cambridge CB2 2QQ, England Univ Oxford, Radcliffe Infirm, Dept Endocrinol, Oxford OX2 7JS, England Univ Oxford Oxford England OX2 7JS t Endocrinol, Oxford OX2 7JS, England
Titolo Testata:
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
fascicolo: 12, volume: 85, anno: 2000,
pagine: 4650 - 4656
SICI:
0021-972X(200012)85:12<4650:IIMAFA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORAL DEHYDROEPIANDROSTERONE; POSTMENOPAUSAL WOMEN; MAJOR DEPRESSION; CORTISOL; SULFATE; MEMORY; DHEA; AGE; ESTROGENS; ANDROGENS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Chatterjee, VKK Univ Cambridge, Addenbrookes Hosp, Dept Med, Level 5,HillsRd, Cambridge CB2 2QQ, England Univ Cambridge Level 5,Hills Rd Cambridge England CB2 2QQ
Citazione:
P.J. Hunt et al., "Improvement in mood and fatigue after dehydroepiandrosterone replacement in Addison's disease in a randomized, double blind trial", J CLIN END, 85(12), 2000, pp. 4650-4656

Abstract

Dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) are adrenal precursors of steroid biosynthesis and centrally acting neurosteroids. Glucocorticoid and mineralocorticoid deficiencies in Addison's disease require life-long hormone replacement, but the associated failure of DHEA synthesis is notcorrected. We conducted a randomized, double blind study in which 39 patients with Addison's disease received either 50 mg oral DHEA daily for 12 weeks, followed by a 1-week washout period, then 12 weeks of placebo, or vice versa. After DHEA treatment, levels of DHEAS and Delta (4)-androstenedione rose from subnormal to within the adult physiological range. Total testosterone increased from subnormal to low normal with a fall in serum sex hormone-binding globulin in females, but with no change in either parameter in males. In both sexes, psychological assessment showed significant enhancementof self-esteem with a tendency for improved overall well-being. Mood and fatigue also improved significantly, with benefit being evident in the evenings. No effects on cognitive or sexual function, body composition,lipids, or bone mineral density were observed. Our results indicate that DHEA replacement corrects this steroid deficiency effectively and improves some aspects of psychological function. Beneficial effects in males, independent of circulating testosterone levels, suggest that it may act directly on the central nervous system rather than by augmenting peripheral androgen biosynthesis. These positive effects, in the absence of significant adverse events, suggest a role for DHEA replacement therapy in the treatment of Addison's disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 00:55:58