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Titolo:
Changes in dehydroepiandrosterone (DHEA) and DHEA-sulfate plasma levels during experimental endotoxinemia in healthy volunteers
Autore:
Schuld, A; Mullington, J; Friess, E; Hermann, DM; Galanos, C; Holsboer, F; Pollmacher, T;
Indirizzi:
Max Planck Inst Psychiat, D-80804 Munich, Germany Max Planck Inst Psychiat Munich Germany D-80804 D-80804 Munich, Germany Max Planck Inst Immunbiol, D-79108 Freiburg, Germany Max Planck Inst Immunbiol Freiburg Germany D-79108 108 Freiburg, Germany
Titolo Testata:
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
fascicolo: 12, volume: 85, anno: 2000,
pagine: 4624 - 4629
SICI:
0021-972X(200012)85:12<4624:CID(AD>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; PITUITARY-ADRENAL AXIS; ADRENOCORTICAL FUNCTION; INFLAMMATORY CYTOKINES; INFECTION; ENDOCRINE; CORTISOL; FETAL; INTERLEUKIN-6; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Schuld, A Max Planck Inst Psychiat, Kraepelinstr 10, D-80804 Munich, Germany Max Planck Inst Psychiat Kraepelinstr 10 Munich Germany D-80804
Citazione:
A. Schuld et al., "Changes in dehydroepiandrosterone (DHEA) and DHEA-sulfate plasma levels during experimental endotoxinemia in healthy volunteers", J CLIN END, 85(12), 2000, pp. 4624-4629

Abstract

Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEA-S) have immunomodulatory effects in vitro and in vivo. Additionally, their plasma levels are altered during chronic infection and inflammation. However, it remains unknownwhether these steroids are involved in early host responses to infection in humans. We examined DHEA and DHEA-S levels during experimental endotoxinemia, a well established pathophysiological model of bacterial infections inhumans. Purified Salmonella abortus equi endotoxin (0.2, 0.4, or 0.8 ng/kgbody weight) was injected in a single-blind, placebo-controlled experimentto 17 healthy male volunteers. During the following 12 h, rectal temperature and the plasma levels of ACTH, cortisol, DHEA, DHEA-S, interleukin 6, and tumor necrosis factor alpha were determined. Confirming earlier studies, temperature and cytokine levels showed monophasic, dose-dependent increasesin response to endotoxin. In contrast, endocrinological effects of endotoxin showed a complex, biphasic pattern: cortisol levels were not affected by0.2 ng/kg but significantly increased during the first 6 h following 0.4 and 0.8 ng/kg endotoxin, whereas ACTH and DHEA levels were significantly enhanced during the first 6 h following 0.8 ng/kg only. ACTH, DHEA, and cortisol secretion was blunted 6-12 h following 0.8 ng/kg. DHEA-S levels were unaffected during the first 6 h following all dosages, but between 6-12 h after injection they were significantly increased following 0.2 ng/kg, unaffected by 0.4 ng/kg, and significantly decreased following 0.8 ng/kg endotoxin. The present results suggest that similarly to glucocorticoids, the adrenalandrogens DHEA and DHEA-S play an important role during early host responses to bacterial infections in humans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 00:52:21