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Titolo:
A TEST OF NEUTRALITY BASED ON INTERLOCUS ASSOCIATIONS
Autore:
KELLY JK;
Indirizzi:
UNIV OREGON,DEPT BIOL EUGENE OR 97403 UNIV CHICAGO,DEPT ECOL & EVOLUT CHICAGO IL 60637
Titolo Testata:
Genetics
fascicolo: 3, volume: 146, anno: 1997,
pagine: 1197 - 1206
SICI:
0016-6731(1997)146:3<1197:ATONBO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACHAETE-SCUTE REGION; DROSOPHILA-MELANOGASTER; DNA POLYMORPHISM; LINKAGE DISEQUILIBRIUM; ALCOHOL-DEHYDROGENASE; NATURAL-POPULATIONS; DELETERIOUS MUTATIONS; COALESCENT PROCESS; STATISTICAL TESTS; X-CHROMOSOME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
J.K. Kelly, "A TEST OF NEUTRALITY BASED ON INTERLOCUS ASSOCIATIONS", Genetics, 146(3), 1997, pp. 1197-1206

Abstract

The evolutionary processes governing variability within genomic regions of low recombination have been the focus of many studies. Here, I investigate the statistical properties of a measure of intrlocus genetic associations under the assumption that mutations are selectively neutral and sites are completely linked. This measure, denoted Z(nS), is based on the squared correlation of allelic identity at pairs of polymorphic sites. Upper bounds for Z(nS) are determined by simulations. Various deviations from the neutral model, including several different forms of natural selection, will inflate the value of Z(nS) relative toits neutral theory expectations. Larger than expected values of Z(nS)are observed in genetic samples from the yellow-ac-scute and Adh regions of Drosophila melanogaster.

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Documento generato il 30/11/20 alle ore 10:16:53