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Titolo:
Repetitive transcranial magnetic stimulation to right prefrontal cortex does not modulate the psychostimulant effects of amphetamine
Autore:
Clark, L; McTavish, SFB; Harmer, CJ; Mills, KR; Cowen, PJ; Goodwin, GM;
Indirizzi:
Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford OX3 7JX, England Univ Oxford Oxford England OX3 7JX ept Psychiat, Oxford OX3 7JX, England Inst Psychiat, London SE5 8AF, England Inst Psychiat London England SE5 8AF t Psychiat, London SE5 8AF, England
Titolo Testata:
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
fascicolo: 4, volume: 3, anno: 2000,
pagine: 297 - 302
SICI:
1461-1457(200012)3:4<297:RTMSTR>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE; DEPRESSION; ATTENTION; DEPLETION; RESPONSES; MANIA; MOOD; NOREPINEPHRINE; NEUROANATOMY; CLONIDINE;
Keywords:
amphetamine; mania; dopamine; transcranial magnetic stimulation; sustained attention;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Goodwin, GM Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford OX3 7JX, England Univ Oxford Oxford England OX3 7JX , Oxford OX3 7JX, England
Citazione:
L. Clark et al., "Repetitive transcranial magnetic stimulation to right prefrontal cortex does not modulate the psychostimulant effects of amphetamine", IN J NEUROP, 3(4), 2000, pp. 297-302

Abstract

Preliminary evidence indicates lateralized efficacy of repetitive transcranial magnetic stimulation (rTMS) in the treatment of mood disorders. Right-sided prefrontal cortex (PFC) stimulation has been reported to treat symptoms of mania. The acute effect of amphetamine serves as a model of mania in healthy individuals, hence rTMS to right PFC was hypothesized to attenuate the psychostimulant action of amphetamine in healthy volunteers. Eighteen subjects received rTMS to right PFC or right parietal cortex (PAR), or sham stimulation, in a randomized between-subjects design. Following rTMS subjects received i.v. amphetamine (0.15 mg/kg). Intravenous amphetamine induced robust subjective (visual analogue scales) and objective (blood pressure, sustained attention) effects, but the extent of the effects was not modulated by right PFC stimulation. Though this dose cannot refute the efficacy of rTMS in treating mania, it indicates that any therapeutic mechanism of action is unlikely to be through modulation of dopamine function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:30:27