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Titolo:
Tryptophan depletion selectively reduces CSF5-HT metabolites in healthy young men: results from single lumbar puncture sampling technique
Autore:
Moreno, FA; McGavin, C; Malan, TP; Gelenberg, AJ; Heninger, GR; Mathe, AA; Delgado, PL;
Indirizzi:
Univ Arizona, Hlth Sci Ctr, Coll Med, Dept Psychiat, Tucson, AZ 85724 USA Univ Arizona Tucson AZ USA 85724 Med, Dept Psychiat, Tucson, AZ 85724 USA Univ Arizona, Hlth Sci Ctr, Coll Med, Dept Anesthesiol, Tucson, AZ USA Univ Arizona Tucson AZ USA r, Coll Med, Dept Anesthesiol, Tucson, AZ USA Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA Yale Univ New Haven CT USA iv, Sch Med, Dept Psychiat, New Haven, CT USA Karolinska Inst, St Gorans Hosp, Dept Clin Neurosci, Stockholm, Sweden Karolinska Inst Stockholm Sweden Dept Clin Neurosci, Stockholm, Sweden Case Western Reserve Univ, Sch Med, Dept Psychiat, Cleveland, OH 44106 USACase Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
fascicolo: 4, volume: 3, anno: 2000,
pagine: 277 - 283
SICI:
1461-1457(200012)3:4<277:TDSRCM>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID TRYPTOPHAN; AMINO-ACID MIXTURES; METHYL-L-TRYPTOPHAN; 5-HYDROXYINDOLEACETIC ACID; SEROTONIN SYNTHESIS; RAPID DEPLETION; LIQUID-CHROMATOGRAPHY; PLASMA TRYPTOPHAN; SERUM TRYPTOPHAN; BRAIN TRYPTOPHAN;
Keywords:
monoamine metabolites; tryptophan depletion; cerebrospinal fluid (CSF);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Moreno, FA Univ Arizona, Hlth Sci Ctr, Coll Med, Dept Psychiat, 1501 N Campbell Ave 7-OPC, Tucson, AZ 85724 USA Univ Arizona 1501 N Campbell Ave 7-OPC Tucson AZ USA 85724 USA
Citazione:
F.A. Moreno et al., "Tryptophan depletion selectively reduces CSF5-HT metabolites in healthy young men: results from single lumbar puncture sampling technique", IN J NEUROP, 3(4), 2000, pp. 277-283

Abstract

Plasma tryptophan (Trp) depletion is a commonly used tool for determining the role of brain serotonin (5-HT) function in a variety of psychiatric disorders. This study measured the cerebrospinal fluid (CSF) monoamine metabolite response to Trp depletion and control testing in five healthy subjects utilizing a single lumbar puncture. Testing was done in a placebo-controlled, double-blind, randomized, cross-over design. Plasma-free and total Trp levels and behavioural ratings were obtained prior to and 5 h after ingestion of each amino-acid drink. CSF was obtained by performing a standard lumbar puncture 7 h after ingestion of the drink. Compared to control testing, Trp depletion caused a significant decrease of CSF 5-hydroxyindoleacetic acid (5-HIAA) (p = 0.03), but not of homovanillic acid or 3-mefhoxy-4-hydroxy-phenylglycol. Behavioural ratings were minimally affected in all subjects. This confirms that plasma Trp depletion reduces central nervous system measures of 5-HT function and suggests that the single lumbar puncture technique may be sufficient to detect the extent of CSF 5-HIAA. changes during Trp depletion studies.

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Documento generato il 19/01/20 alle ore 20:34:41