Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Olanzapine-induced leukopenia with human leukocyte antigen profiling
Autore:
Buchman, N; Strous, RD; Ulman, AM; Lerner, M; Kotler, M;
Indirizzi:
Tel Aviv Univ, Sackler Sch Med, Beer Yaakov Mental Hlth Ctr, IL-70350 BeerYaakov, Israel Tel Aviv Univ Beer Yaakov Israel IL-70350 r, IL-70350 BeerYaakov, Israel Ben Gurion Univ Negev, IL-84105 Beer Sheva, Israel Ben Gurion Univ Negev Beer Sheva Israel IL-84105 4105 Beer Sheva, Israel
Titolo Testata:
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
fascicolo: 1, volume: 16, anno: 2001,
pagine: 55 - 57
SICI:
0268-1315(200101)16:1<55:OLWHLA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLOZAPINE-INDUCED AGRANULOCYTOSIS; HLA-B38;
Keywords:
agranulocytosis; clozapine; HLA typing; leukopenia; olanzapine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Strous, RD Tel Aviv Univ, Sackler Sch Med, Beer Yaakov Mental Hlth Ctr, POB 1, IL-70350 Beer Yaakov, Israel Tel Aviv Univ POB 1 Beer Yaakov Israel IL-70350 Yaakov, Israel
Citazione:
N. Buchman et al., "Olanzapine-induced leukopenia with human leukocyte antigen profiling", INT CLIN PS, 16(1), 2001, pp. 55-57

Abstract

Olanzapine is an atypical antipsychotic medication frequently used in the management of psychotic states. While it has proved to be safe compared to clozapine with regard to haematotoxicity, because it has only been available for a few years, full documentation of its haematological side-effects remains incomplete. We report a case of olanzapine-induced leukopenia with associated neutropenia. Since clozapine-induced haematotoxicity has been associated with characteristic human leukocyte antigen (HLA) groups, HLA typingwas determined in this patient. Following failure with typical antipsychotic medication, the patient received 10 mg/day of olanzapine. Three weeks later, he developed fever and a significant decrease in leukocyte count. Olanzapine was immediately discontinued. HLA typing was determined. The white cell count returned to normal and the fever, most probably secondary to the low white cell count, subsided with antibiotic treatment. HLA typing results were: A1 24, B7, B35, DRB1*15, DRB1*11, DRB3*01-03, DRB5*01-02. Olanzapine may induce serious leukopenia and neutropenia. HLA typing in this single patient demonstrated a distinct haplotype compared to that previously observed in clozapine-induced haematoxicity. Int. clin. Psychopharmacol 16:55-57(C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:01:47