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Titolo:
Triggering receptors involved in natural killer cell-mediated cytotoxicityagainst choriocarcinoma cell lines
Autore:
Sivori, S; Parolini, S; Marcenaro, E; Millo, R; Bottino, C; Moretta, A;
Indirizzi:
Univ Genoa, Dipartimento Med Sperimentale, Sez Istol, I-16132 Genoa, ItalyUniv Genoa Genoa Italy I-16132 imentale, Sez Istol, I-16132 Genoa, Italy Univ Brescia, Dipartimento Sci Biomed & Biotecnol, Brescia, Italy Univ Brescia Brescia Italy mento Sci Biomed & Biotecnol, Brescia, Italy Ist Nazl Ric Canc, I-16132 Genoa, Italy Ist Nazl Ric Canc Genoa Italy I-16132 azl Ric Canc, I-16132 Genoa, Italy
Titolo Testata:
HUMAN IMMUNOLOGY
fascicolo: 11, volume: 61, anno: 2000,
pagine: 1055 - 1058
SICI:
0198-8859(200011)61:11<1055:TRIINK>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
HLA-G; INHIBITORY RECEPTORS; HUMAN TROPHOBLAST; NK LYSIS; RECOGNITION; COMPLEX; LYMPHOCYTES; RESISTANCE; PREGNANCY; DECIDUA;
Keywords:
natural cytotoxicity; triggering receptors; trophoblast;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Moretta, A Univ Genoa, Dipartimento Med Sperimentale, Sez Istol, Via GB Marsano 10, I-16132 Genoa, Italy Univ Genoa Via GB Marsano 10 Genoa Italy I-16132 Genoa, Italy
Citazione:
S. Sivori et al., "Triggering receptors involved in natural killer cell-mediated cytotoxicityagainst choriocarcinoma cell lines", HUMAN IMMUN, 61(11), 2000, pp. 1055-1058

Abstract

The lack of classical HLA-class I molecules on trophoblast is necessary toprevent allorecognition by maternal CTL, bur may induce activation of NK cells. A protective role against NK cells equipped of suitable inhibitory receptors has been proposed for nonclassical HLA-class I molecules including HLA-E and HLA-G. In the present study we show that the NK-mediated killing of two choriocarcinoma cell lines, JAR and JEG3, is induced upon engagementof natural cytotoxicity receptors (NCR) with their specific ligands. In particular, we show that NKp44, a triggering receptor expressed at the NK cell surface only after in vitro culture in the presence of IL-2, plays a central role in triggering NK cytotoxicity against trophoblast cells. Also NKp46 appear to contribute to this function by cooperating with NKp44. On the other hand, other triggering receptors such as NKp30, 2B4, and NKG2D are notinvolved in killing of choriocarcinoma. Our findings suggest that resistance of trophoblast to NK-mediated cytotoxicity is the result of insufficientactivating interactions between the various triggering NK receptors and their target cell ligands. On the other hand, the interaction of nonclassicalHLA class I molecules with inhibitory NK receptors appears to play only a marginal role in regulating the susceptibility of choriocarcinoma to NK mediated cytotoxicity. (C) American Society for Histocompatibility and Immunogenetics, 2000. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 10:43:52