Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Basal levels of adenosine modulate mGluR5 on rat hippocampal astrocytes
Autore:
Cormier, RJ; Mennerick, S; Melbostad, H; Zorumski, CF;
Indirizzi:
Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA WashingtonUniv St Louis MO USA 63110 pt Psychiat, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 & Neurobiol, St Louis, MO 63110 USA
Titolo Testata:
GLIA
fascicolo: 1, volume: 33, anno: 2001,
pagine: 24 - 35
SICI:
0894-1491(200101)33:1<24:BLOAMM>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOTROPIC GLUTAMATE RECEPTORS; INTRACELLULAR CALCIUM; PHARMACOLOGICAL CHARACTERIZATION; INOSITOL 1,4,5-TRISPHOSPHATE; SYNAPTIC TRANSMISSION; ENDOGENOUS ADENOSINE; CAMP ACCUMULATION; NERVE-TERMINALS; A(1) RECEPTORS; GLIAL CALCIUM;
Keywords:
calcium imaging; Fura-2; hippocampus; adenosine; purine; pertussis toxin; mastoparan;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Zorumski, CF Washington Univ, Sch Med, Dept Psychiat, 4940 Childrens Pl, St Louis, MO 63110 USA Washington Univ 4940 Childrens Pl St Louis MO USA 63110 0 USA
Citazione:
R.J. Cormier et al., "Basal levels of adenosine modulate mGluR5 on rat hippocampal astrocytes", GLIA, 33(1), 2001, pp. 24-35

Abstract

Neuronal activity elicits increases in intracellular Ca2+ in astrocytes, which in turn can elevate neuronal Ca2+ and potentiate the efficacy of excitatory synaptic transmission. Therefore, understanding the modulation of astrocyte Ca2+ elevations by neurotransmitters should aid in understanding astrocyte-neuronal interactions. On cultured hippocampal microislands containing only astrocytes, activation of metabotropic glutamate receptors (mGluRs)with the specific agonist 1S,3R-ACPD triggers Ca2+ elevations that are potentiated by adenosine A1 receptor activation. A1 receptor modulation of mGluR-induced Ca2+ elevations is blocked by pertussis toxin and is mimicked bythe wasp venom peptide mastoparan, suggesting that potentiation occurs by means of a G(i/o) mechanism. Surprisingly, on microislands containing only astrocytes, A1 receptor antagonism or adenosine degradation suppresses mGluR-triggered Ca2+ elevations, strongly suggesting that astrocytes are a source of physiologically relevant concentrations of adenosine. GLIA 33:24-35, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 04:09:49