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Titolo:
Evidence for RAD5ILI/HMGIC fusion in the pathogenesis of uterine leiomyoma
Autore:
Takahashi, T; Nagai, N; Oda, H; Ohama, K; Kamada, N; Miyagawa, K;
Indirizzi:
Hiroshima Univ, Res Inst Radiat Biol & Med, Dept Mol Pathol, Minato Ku, Hiroshima 7348553, Japan Hiroshima Univ Hiroshima Japan 7348553 nato Ku, Hiroshima 7348553, Japan Hiroshima Univ, Sch Med, Dept Obstet & Gynecol, Hiroshima 7348553, Japan Hiroshima Univ Hiroshima Japan 7348553 Gynecol, Hiroshima 7348553, Japan Tsuchiya Gen Hosp, Hiroshima, Japan Tsuchiya Gen Hosp Hiroshima JapanTsuchiya Gen Hosp, Hiroshima, Japan Hiroshima Univ, Res Inst Radiat Biol & Med, Dept Canc Cytogenet, Minato Ku, Hiroshima 7348553, Japan Hiroshima Univ Hiroshima Japan 7348553 nato Ku, Hiroshima 7348553, Japan
Titolo Testata:
GENES CHROMOSOMES & CANCER
fascicolo: 2, volume: 30, anno: 2001,
pagine: 196 - 201
SICI:
1045-2257(200102)30:2<196:EFRFIT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARCHITECTURAL TRANSCRIPTION FACTOR; FACTOR HMGI-C; DNA-BINDING; REPAIR GENE; EXPRESSION; DISRUPTION; PROTEINS; TUMORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Miyagawa, K Hiroshima Univ, Res Inst Radiat Biol & Med, Dept Mol Pathol, Minato Ku, 1-2-3 Kasumi, Hiroshima 7348553, Japan Hiroshima Univ 1-2-3 Kasumi Hiroshima Japan 7348553 53, Japan
Citazione:
T. Takahashi et al., "Evidence for RAD5ILI/HMGIC fusion in the pathogenesis of uterine leiomyoma", GENE CHROM, 30(2), 2001, pp. 196-201

Abstract

Chromosome rearrangements involving 12q15 are frequently observed in a variety of human mesenchymal tumors. The high mobility group protein gene HMGIC has been identified as the target involved in these rearrangements. Uterine leiomyomas frequently use chromosome band 14q24 as a translocation partner to HMGIC. Recent studies within the chromosome 14 breakpoint region in cell lines carrying t(12;14)(q15;q23-24) revealed that RAD51L1, a member of the RAD51 recombination gene family, is the HMGIC partner. Using RT-PCR, wescreened a panel of 81 uterine leiomyomas removed from 30 women for rearrangement between RAD51L1 and HMGIC. This is the first molecular analysis in which primary tumors have been examined for the RAD51L1/HMGIC transcripts. The chimeric transcripts were identified from two cases in which exon 7 of the RAD51L1 gene is fused in frame to either exon 2 or exon 3 of the HMGIC gene. These transcripts encode fusion proteins containing RAD51L1 nucleotide binding domains and the HMGIC protein lacking the N-terminal AT hook motifs. The detection of the RAD51L1/HMGIC fusion in primary tumors adds to theaccumulating evidence implicating this fusion in a proportion of uterine leiomyoma patients. (C) 2001 Wiley-Liss. Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 19:55:59