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Titolo:
Chromosome bands Ip35-36 contain two distinct neuroblastoma tumor suppressor loci, one of which is imprinted
Autore:
Caron, H; Spieker, N; Godfried, N; Veenstra, M; van Sluis, P; de Kraker, J; Voute, P; Versteeg, R;
Indirizzi:
Univ Amsterdam, Acad Med Ctr, Inst Human Genet, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Emma Kinderziekenhuis, Dept Paediat Oncol & Haematol, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands
Titolo Testata:
GENES CHROMOSOMES & CANCER
fascicolo: 2, volume: 30, anno: 2001,
pagine: 168 - 174
SICI:
1045-2257(200102)30:2<168:CBICTD>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
N-MYC AMPLIFICATION; GENE-MUTATIONS; SHORT ARM; 1P; DELETION; HETEROZYGOSITY; ASSOCIATION; REGION; HYBRIDIZATION; INSTABILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Caron, H Univ Amsterdam, Acad Med Ctr, Dept Human Genet, POB 22700, NL-1011 DE Amsterdam, Netherlands Univ Amsterdam POB 22700 Amsterdam NetherlandsNL-1011 DE rlands
Citazione:
H. Caron et al., "Chromosome bands Ip35-36 contain two distinct neuroblastoma tumor suppressor loci, one of which is imprinted", GENE CHROM, 30(2), 2001, pp. 168-174

Abstract

A previous loss of heterozygosity (LOH) study of a series of 91 neuroblastomas suggested that the 1p35-36 region encodes at least two tumor suppressor genes (TSGs) of importance in neuroblastoma development. Here we present the results of a study including 205 neuroblastomas that were analyzed for LOH at chromosome 1 and MYCN amplification. The results corroborate the existence of two TSGs on 1p. Distinct 1p loci seem to be involved in MYCN single copy vs. MYCN amplified neuroblastoma, as these tumors display a different type of shortest region of overlap (SRO). About 15% of MYCN single copy neuroblastomas show 1p deletions of variable length with an SRO of 47 cR at1p36.3. The lost alleles are preferentially of maternal origin (P = 0.0002), suggesting parental imprinting of the locus. MYCN amplified neuroblastomas have a contrasting pattern of 1p loss. These tumors display much larger deletions of at least 89 cR comprising the region from 1p36.1 to the telomere. LOH of 1p is detected in 86% of the cases. The lost alleles are of random parental origin, suggesting inactivation of a non-imprinted TSG. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 19:44:46