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Titolo:
NADPH oxidase activity is required for endothelial cell proliferation and migration
Autore:
Abid, MR; Kachra, Z; Spokes, KC; Aird, WC;
Indirizzi:
Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA Beth Israel Deaconess Med Ctr Boston MA USA 02215 d, Boston, MA 02215 USA Beth Israel Deaconess Med Ctr, Dept Mol Med, Boston, MA 02215 USA Beth Israel Deaconess Med Ctr Boston MA USA 02215 d, Boston, MA 02215 USA
Titolo Testata:
FEBS LETTERS
fascicolo: 3, volume: 486, anno: 2000,
pagine: 252 - 256
SICI:
0014-5793(200012)486:3<252:NOAIRF>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR SMOOTH-MUSCLE; NF-KAPPA-B; SUPPRESSES TUMOR-GROWTH; ANGIOTENSIN-II; SIGNAL-TRANSDUCTION; ACTIVATION; ANGIOGENESIS; APOPTOSIS; EXPRESSION; INHIBITION;
Keywords:
NADPH oxidase; reactive oxygen species; endothelial cell; proliferation; migration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Aird, WC Beth Israel Deaconess Med Ctr, Dept Med, RW-663,330 Brookline Ave, Boston,MA 02215 USA Beth Israel Deaconess Med Ctr RW-663,330 Brookline Ave Boston MA USA 02215
Citazione:
M.R. Abid et al., "NADPH oxidase activity is required for endothelial cell proliferation and migration", FEBS LETTER, 486(3), 2000, pp. 252-256

Abstract

NADPH oxidase has been shown to play an important role in cardiovascular biology. The goal of the present study,vas to determine whether NADPH oxidase activity is important for endothelial cell growth and migration. In proliferation assays, growth factor- or serum-induced DNA synthesis in three different types of human endothelial cells was abrogated by inhibitors of NADPH oxidase, but not by inhibitors of xanthine oxidase or nitric oxide synthase, Moreover, vascular endothelial growth factor-induced migration of humanendothelial cells mas suppressed in the presence of NADPH oxidase inhibitors. These results support a potential role for NADPH oxidase in mediating angiogenesis. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 21:34:48