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Titolo:
Chronic intracerebroventricular exposure to beta-amyloid(1-40) impairs object recognition but does not affect spontaneous locomotor activity or sensorimotor gating in the rat
Autore:
Nag, S; Tang, F; Yee, BK;
Indirizzi:
Univ Hong Kong, Fac Med, Dept Anat, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China Univ Hong Kong, Fac Med, Dept Physiol, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China
Titolo Testata:
EXPERIMENTAL BRAIN RESEARCH
fascicolo: 1, volume: 136, anno: 2001,
pagine: 93 - 100
SICI:
0014-4819(200101)136:1<93:CIETBI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-AMYLOID PROTEIN; NUCLEUS BASALIS MAGNOCELLULARIS; ACOUSTIC STARTLE RESPONSE; ALZHEIMERS-DISEASE; PREPULSE INHIBITION; NEUROTOXIC LESIONS; FORNIX TRANSECTION; RADIAL-MAZE; EXCITOTOXIC LESIONS; CHOLINERGIC SYSTEM;
Keywords:
acetylcholine; Alzheimer's disease; physostigmine; prepulse inhibition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Yee, BK Univ Hong Kong, Fac Med, Dept Anat, 5 Sassoon Rd, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong 5 Sassoon Rd Hong Kong Hong Kong Peoples R China a
Citazione:
S. Nag et al., "Chronic intracerebroventricular exposure to beta-amyloid(1-40) impairs object recognition but does not affect spontaneous locomotor activity or sensorimotor gating in the rat", EXP BRAIN R, 136(1), 2001, pp. 93-100

Abstract

This study examined the cognitive effects of chronic in vivo exposure to beta -amyloid(1-40) via the intracerebroventricular route on two distinct paradigms. The first test evaluated a form of early attentional control referred to as sensorimotor gating in which an antecedent weak prepulse stimulusmodulates the reactivity to a subsequent startle-eliciting stimulus. The second test utilized the spontaneous preference for a novel object over thatof a familiar one in rats as a measure of object recognition memory. We found that beta -amyloid exposure leads to a severe deficit in the object memory test but spares sensorimotor gating. Moreover, unlike the water maze deficit induced by beta -amyloid (Nag et al., in preparation), the deficit onobject recognition was resistant to amelioration by systemic physostigminetreatment at a dose of 0.06 mg/kg per day intraperitoneally. The present results add to previous reports that beta -amyloid exposure can lead to deficits on hippocampal lesion sensitive tasks, suggesting that dysfunction of the rhinal cortices in addition to that of the septohippocampal system is implicated in beta -amyloid-induced behavioral impairments. It therefore lends support to the hypothesis that beta -amyloid exposure can lead to severeimpairment across multiple memory systems.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/10/20 alle ore 10:51:29