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Titolo:
In vitro study on fluoxetine adsorption onto charcoal using potentiometry
Autore:
Atta-Politou, J; Skopelitis, I; Apatsidis, I; Koupparis, M;
Indirizzi:
Univ Athens, Dept Chem, Analyt Chem Lab, GR-15771 Athens, Greece Univ Athens Athens Greece GR-15771 lyt Chem Lab, GR-15771 Athens, Greece
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
fascicolo: 3, volume: 12, anno: 2001,
pagine: 311 - 319
SICI:
0928-0987(200101)12:3<311:IVSOFA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ION-SELECTIVE ELECTRODES; BOVINE SERUM-ALBUMIN; ACTIVATED-CHARCOAL; POLYETHYLENE-GLYCOL; PHARMACOKINETIC PROPERTIES; DEPRESSIVE-ILLNESS; LAVAGE SOLUTION; BINDING; CYCLODEXTRINS; DESORPTION;
Keywords:
fluoxetine; adsorption; charcoal; ion selective electrode potentiometry; antidotal efficacy; adsorption kinetic study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Atta-Politou, J Univ Athens, Dept Chem, Analyt Chem Lab, GR-15771 Athens, Greece Univ Athens Athens Greece GR-15771 -15771 Athens, Greece
Citazione:
J. Atta-Politou et al., "In vitro study on fluoxetine adsorption onto charcoal using potentiometry", EUR J PH SC, 12(3), 2001, pp. 311-319

Abstract

This in vitro investigation was performed to study the adsorption rate constant as well as the adsorption characteristics of fluoxetine (F) to activated charcoal and its commercial formulation Carbomix powder in simulated gastric (pH 1.2) fluid environment. Ion-selective electrode (ISE) potentiometry, based on the selective, direct and continuous monitoring of F with an F-ISE constructed in our laboratory was used. The method used in the kineticexperiments consists of the rapid addition of a slurry containing the charcoal into the drug solution under stirring and continuous recording of the F-ISE potential until the establishment of equilibrium. The free ionized drug concentration at appropriate time intervals was calculated from the recorded adsorption curve and the apparent adsorption rate constant was estimated assuming pseudo first order kinetics. Within run R.S.D. of the estimatesranged from 0.24 to 11.5%, while between run R.S.D. (n=3-4) ranged from 0.90 to 13.8%. A linear relationship was found between the apparent adsorption rate constants and the amount of charcoal used with slopes (+/-S.D.) for activated charcoal and Carbomix equal to 1.14(+/-0.21) and 0.146(+/-0.009) s(-1) g(-1), respectively. Successive additions of microvolumes of F solution were made into a charcoal slurry with measurement of the F-ISE potentialat equilibrium. The maximum adsorption capacity values (+/-S.D.) of activated charcoal and Carbomix were 254.8+/-1.8 and 405+/-41 mg/g, respectively while the affinity constant values (+/-S.D.) were 45.6+/-2.2 and 55.5+/-2.91/g, respectively. The adsorption of F to charcoals was rapid and for amounts of charcoal 10 times greater than the amount of the drug, 95% of F was adsorbed within the first 5 min. Relative to the toxic and lethal doses in cases of F intoxications, both types of charcoals tested adsorbed effectively F at gastric pH. Carbomix can be considered as appropriate charcoal formulation for medical treatment in cases of F poisoning. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 09:48:38