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Titolo:
Limited usefulness of a seven-day twice-a-day quadruple therapy
Autore:
Garcia, N; Calvet, X; Gene, E; Campo, R; Brullet, E;
Indirizzi:
Corp Sanitaria Parc Tauli, Dept Surg, Barcelona 08208, Spain Corp Sanitaria Parc Tauli Barcelona Spain 08208 , Barcelona 08208, Spain
Titolo Testata:
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
fascicolo: 12, volume: 12, anno: 2000,
pagine: 1315 - 1318
SICI:
0954-691X(200012)12:12<1315:LUOAST>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
HELICOBACTER-PYLORI INFECTION; TRIPLE THERAPIES; ERADICATION; CLARITHROMYCIN; LANSOPRAZOLE; METRONIDAZOLE; MULTICENTER; AMOXICILLIN; RESISTANCE; REGIMENS;
Keywords:
Helicobacter pylori; quadruple therapy; treatment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Calvet, X Corp Sanitaria Parc Tauli, Serv Med, Parc Tauli S-N, Barcelona 08208, Spain Corp Sanitaria Parc Tauli Parc Tauli S-N Barcelona Spain 08208
Citazione:
N. Garcia et al., "Limited usefulness of a seven-day twice-a-day quadruple therapy", EUR J GASTR, 12(12), 2000, pp. 1315-1318

Abstract

Objective To test the usefulness of a twice-a-day. simplified quadruple therapy to cure Helicobacter pylori infection. Design Helicobacter pylori-positive ulcer patients were treated with omeprazole 20 mg twice a day (b.d.), amoxicillin 1 g b.d., tinidazole 500 mg b.d, and bismuth subcitrate 240 mg b.d. for 7 days in an experimental, noncomparative pilot study. Setting The gastroenterology unit of a county hospital. Participants Forty-four consecutive patients with peptic ulcer disease andH. pylori infection. Measurements Cure was tested by either endoscopy or breath test after 2 months, and by urea breath test 6 months after therapy. Results One patient was lost to follow-up. Of the remaining 43, 37 were cured at the first control, giving an intention-to-treat cure rate of 84.1% (95% CI 69-93%) and a per protocol cure rate of 86% (95% CI 71-94%). Thirty-three cured patients agreed to return for a six-month breath test All but one were cured (long-term per protocol cure rate 82.1%; 95% CI 66-92%). Conclusions This particular quadruple therapy is well tolerated and easy to comply with. However, cure rates did not reach 90%. Eur J Gastroenterol Hepatol 12:1315-1318 (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 17:58:56