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Titolo:
Leptin and the treatment of obesity
Autore:
Walder, K; de Silva, A;
Indirizzi:
Deakin Univ, Sch Hlth Sci, Geelong, Vic 3217, Australia Deakin Univ Geelong Vic Australia 3217 Sci, Geelong, Vic 3217, Australia Int Diabet Inst, Caulfield, Vic, Australia Int Diabet Inst Caulfield Vic Australia Inst, Caulfield, Vic, Australia
Titolo Testata:
DRUG DEVELOPMENT RESEARCH
fascicolo: 2, volume: 51, anno: 2000,
pagine: 66 - 79
SICI:
0272-4391(200010)51:2<66:LATTOO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISOLATED RAT ADIPOCYTES; RECEPTOR MESSENGER-RNA; OB GENE-EXPRESSION; SYMPATHETIC-NERVE ACTIVITY; BODY-FAT DISTRIBUTION; WHITE ADIPOSE-TISSUE; PREDICT WEIGHT-GAIN; PLASMA LEPTIN; FOOD-INTAKE; PSAMMOMYS-OBESUS;
Keywords:
leptin; obesity treatment; ob gene;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
155
Recensione:
Indirizzi per estratti:
Indirizzo: Walder, K Deakin Univ, Sch Hlth Sci, Geelong, Vic 3217, Australia Deakin Univ Geelong Vic Australia 3217 ong, Vic 3217, Australia
Citazione:
K. Walder e A. de Silva, "Leptin and the treatment of obesity", DRUG DEV R, 51(2), 2000, pp. 66-79

Abstract

The cloning of the ob gene and subsequent discovery of the weight-reducingprotein leptin has revitalized research into body weight regulation and raised the possibility of effective pharmaceutical control of the energy balance. Leptin is secreted from adipocytes in proportion to fat mass in both humans and rodents, and circulating leptin is thought to act on the hypothalamus to inhibit feeding and stimulate energy expenditure. Hyperleptinemia appears to accompany human obesity, suggesting the development of resistanceto leptin's anorexigenic actions, although it was hoped that this resistance could be overcome by administration of exogenous leptin. Results from clinical trials suggest that the response to leptin administration is variable, and while this may be an effective treatment for obesity in some individuals, it is unlikely to be a universal treatment for the disease. Current research has now turned to examining the factors involved in potentiating leptin's effects in the brain and the search for leptin analogs or neuropeptides involved in regulating the leptin pathway is under way in earnest, as these may yet prove to be the key to effective treatment for human obesity. (C) 2000 Wiley-Liss, Inc.

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Documento generato il 25/11/20 alle ore 01:35:01