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Titolo:
Thrice-weekly supervised dosing with the combination buprenorphine-naloxone tablet is preferred to daily supervised dosing by opioid-dependent humans
Autore:
Amass, L; Kamien, JB; Mikulich, SK;
Indirizzi:
Univ Colorado, Sch Med, Dept Psychiat, Denver, CO 80206 USA Univ ColoradoDenver CO USA 80206 ed, Dept Psychiat, Denver, CO 80206 USA BioPsych Consulting, Sherman Oaks, CA 91403 USA BioPsych Consulting Sherman Oaks CA USA 91403 Sherman Oaks, CA 91403 USA
Titolo Testata:
DRUG AND ALCOHOL DEPENDENCE
fascicolo: 2, volume: 61, anno: 2001,
pagine: 173 - 181
SICI:
0376-8716(20010101)61:2<173:TSDWTC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHADONE-MAINTENANCE TREATMENT; ADDICTION SEVERITY INDEX; HEROIN DEPENDENCE; CLINICAL-TRIAL; COCAINE USE; WITHDRAWAL; VOLUNTEERS; LIQUID; RISK;
Keywords:
buprenorphine; buprenorphine-naloxone; dosing regimen; abuse; pharmacotherapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Amass, L Friends Res Inst Inc, Los Angeles Addict Treatment Res Ctr, 11075Santa Monica Blvd,Suite 225, Los Angeles, CA 90025 USA Friends Res Inst Inc 11075 Santa Monica Blvd,Suite 225 Los Angeles CA USA 90025
Citazione:
L. Amass et al., "Thrice-weekly supervised dosing with the combination buprenorphine-naloxone tablet is preferred to daily supervised dosing by opioid-dependent humans", DRUG AL DEP, 61(2), 2001, pp. 173-181

Abstract

A sublingual tablet formulation of buprenorphine combining 8 mg of buprenorphine with 2 mg of naloxone is being targeted for use in settings where less than daily dosing strategies and/or prescription-based dispensing will likely be employed. This study determined patient preferences for, and clinical outcomes during, daily and 3-day per week supervised dosing schedules using the combination tablet. Twenty-four opioid-dependent subjects completing a 16-day baseline entered an outpatient triple crossover trial. Twenty-one days of daily dosing were compared to two different 21-day periods of 3-day per week supervised dosing: a 3-day per week clinic schedule and a 3-day per week take-home schedule in which tablets were provided to subjects totake at home on days between clinic visits. Thirteen patients completed the study. Significantly more doses were ingested under the 3-day per week schedules. Illicit drug use did not differ across conditions and 45% of urinesamples tested positive for illicit opioids. Subjects 'liked' both 3-day per week schedules more than the daily schedule, and ratings of feeling 'good' were higher for the 3-day take-home as opposed to 3-day clinic condition. Almost all subjects (91%) rated 3-day take-home as the most preferred schedule. Overall, reducing clinic attendance improved medication compliance and increased client satisfaction without impacting illicit drug use. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 11:48:55