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Titolo:
Effectiveness of different vaccine formulations against vibriosis caused by Vibrio vulnificus serovar E (biotype 2) in European eels Anguilla anguilla
Autore:
Collado, R; Fouz, B; Sanjuan, E; Amaro, C;
Indirizzi:
Univ Valencia, Fac Biol, Dept Microbiol & Ecol, E-46100 Burjassot, Spain Univ Valencia Burjassot Spain E-46100 l & Ecol, E-46100 Burjassot, Spain
Titolo Testata:
DISEASES OF AQUATIC ORGANISMS
fascicolo: 2, volume: 43, anno: 2000,
pagine: 91 - 101
SICI:
0177-5103(20001114)43:2<91:EODVFA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCOPHTHALMUS-MAXIMUS L; TROUT ONCORHYNCHUS-MYKISS; RAINBOW-TROUT; ANTIBODY-RESPONSE; GILTHEAD SEABREAM; IMMUNE-RESPONSE; SEA BASS; LIPOPOLYSACCHARIDE; TURBOT; VIRULENCE;
Keywords:
Vibrio vulnificus serovar E; Vibrio vulnificus biotype 2; eel vaccines; vibrio vaccines; vaccination by injection; vaccination by prolonged immersion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Amaro, C Univ Valencia, Fac Biol, Dept Microbiol & Ecol, E-46100 Burjassot, Spain Univ Valencia Burjassot Spain E-46100 E-46100 Burjassot, Spain
Citazione:
R. Collado et al., "Effectiveness of different vaccine formulations against vibriosis caused by Vibrio vulnificus serovar E (biotype 2) in European eels Anguilla anguilla", DIS AQU ORG, 43(2), 2000, pp. 91-101

Abstract

Vibriosis due to Vibrio vulnificus serovar E (biotype 2) is one of the main causes of mortality in European eels cultured in Europe. The main objective of this study was to develop a vaccine and a vaccination procedure against this pathogen. With this aim, we tested several vaccine formulations (inactivated whole-cells with and without toxoids-inactivated extracellular products-from capsulated and uncapsulated strains, attenuated live vaccines and purified lipopolysaccharide [LPS]) on eels maintained under controlled laboratory conditions using different delivery routes (injection and immersion). To study the immune response we estimated antibody titers and bactericidal/bacteriostatic activity in mucus and serum. To evaluate protection, wecalculated the relative percent survival (RPS) after intraperitoneal (i.p.) injection and bath challenge of the pathogen. The overall results indicate that: (1) capsular antigens seem to be essential for protective immunization; (2) vaccines confer the highest protection when administered by i.p. injection; (3) booster is needed to achieve good protection by immersion; (4) enriching the vaccine with toxoids enhances protection to optimal levels (RPS values around 70 to 100 %, depending on the delivery route); and (5) the protective effect in serum and mucus depends on the route of administration and seems to be related to the production of specific antibodies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 08:23:38