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Titolo:
Islet autoantibodies in the prediction of diabetes in school children
Autore:
Samuelsson, U; Sundkvist, G; Borg, H; Fernlund, P; Ludvigsson, J;
Indirizzi:
Linkoping Univ, Div Pediat, Dept Hlth & Environm, S-58185 Linkoping, Sweden Linkoping Univ Linkoping Sweden S-58185 ironm, S-58185 Linkoping, Sweden Univ Lund, Malmo Univ Hosp, Dept Endocrinol, Malmo, Sweden Univ Lund Malmo Sweden Malmo Univ Hosp, Dept Endocrinol, Malmo, Sweden Univ Lund, Malmo Univ Hosp, Dept Clin Chem, Malmo, Sweden Univ Lund Malmo Sweden , Malmo Univ Hosp, Dept Clin Chem, Malmo, Sweden
Titolo Testata:
DIABETES RESEARCH AND CLINICAL PRACTICE
fascicolo: 1, volume: 51, anno: 2001,
pagine: 51 - 57
SICI:
0168-8227(200101)51:1<51:IAITPO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMIC-ACID DECARBOXYLASE; CELL ANTIBODIES; GENERAL-POPULATION; MELLITUS; IDDM; RELATIVES; RISK; DISEASE; SWEDEN; ASSAY;
Keywords:
autoantibodies; Type 1 diabetes; prediction; schoolchildren;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Samuelsson, U Linkoping Univ, Div Pediat, Dept Hlth & Environm, S-58185 Linkoping, Sweden Linkoping Univ Linkoping Sweden S-58185 Linkoping, Sweden
Citazione:
U. Samuelsson et al., "Islet autoantibodies in the prediction of diabetes in school children", DIABET RE C, 51(1), 2001, pp. 51-57

Abstract

In 1987 serum was collected from 1031 non-diabetic schoolchildren in the Southeast area of Sweden with the aim of evaluating islet autoantibody status (ICA, GADA and IA2-ab) in the prediction of diabetes in schoolchildren. The clinical development of Type 1 diabetes in the children was assessed in 1994 and 1997. The combination of ICA, GADA and IA2-ab were found in four subjects whereas six had two and 35 children one of these antibodies. After 10 years, six of the 1031 children had developed clinical diabetes and fiveof these six children were positive for islet antibodies. Two were positive for all three antibodies, two were positive for ICA and GADA, and one waspositive for GADA. Among the individual autoantibodies, ICA showed the highest positive predictive value (29%) whereas the predictive value for the combination of two autoantibodies was highest for GADA and ICA (40%). Thus, GADA and ICA measurements may be a rational approach to detect schoolchildren at risk for developing diabetes. (C) 2001 Elsevier Science Ireland Ltd. Ail rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:00:53