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Titolo:
DRacGAP, a novel Drosophila gene, inhibits EGFR/Ras signalling in the developing imaginal wing disc
Autore:
Sotillos, S; Campuzano, S;
Indirizzi:
CSIC, Ctr Biol Mol Severo Ochoa, E-28049 Madrid, Spain CSIC Madrid SpainE-28049 r Biol Mol Severo Ochoa, E-28049 Madrid, Spain UAM Cantoblanco, E-28049 Madrid, Spain UAM Cantoblanco Madrid Spain E-28049 Cantoblanco, E-28049 Madrid, Spain
Titolo Testata:
DEVELOPMENT
fascicolo: 24, volume: 127, anno: 2000,
pagine: 5427 - 5438
SICI:
0950-1991(200012)127:24<5427:DANDGI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-SHAPE CHANGES; SIGNALING PATHWAY; RHO GTPASES; PLANAR POLARIZATION; PATTERN-FORMATION; RECEPTOR PATHWAY; PROTEIN-KINASE; CYCLE ARREST; EXPRESSION; GROWTH;
Keywords:
RacGAP; Rac GTPase; signal transduction; apoptosis; EGFR; Drosophila melanogaster; Imaginal disc;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: Campuzano, S CSIC, Ctr Biol Mol Severo Ochoa, Plaza Murillo 2, E-28049 Madrid, Spain CSIC Plaza Murillo 2 Madrid Spain E-28049 8049 Madrid, Spain
Citazione:
S. Sotillos e S. Campuzano, "DRacGAP, a novel Drosophila gene, inhibits EGFR/Ras signalling in the developing imaginal wing disc", DEVELOPMENT, 127(24), 2000, pp. 5427-5438

Abstract

We have identified a novel Drosophila gene, DRacGAP, which behaves as a negative regulator of Rho-family GTPases DRac1 and DCdc42, Reduced function of DRacGAP or increased expression of DRac1 in the wing imaginal disc cause similar effects on vein and sensory organ development and cell proliferation. These effects result from enhanced activity of the EGFR/Ras signalling pathway. We find that in the wing disc, DRac1 enhances EGFR/Ras-dependent activation of MAP Kinase in the prospective veins. Interestingly, DRacGAP expression is negatively regulated by the EGFR/Ras pathway in these regions. During vein formation, local DRacGAP repression would ensure maximal activity of Rac and, in turn, of Ras pathways in vein territories. Additionally, maximal expression of DRacGAP at the vein/intervein boundaries would help torefine the width of the veins. Hence, control of DRacGAP expression by theEGFR/Ras pathway is a previously undescribed feedback mechanism modulatingthe intensity and/or duration of its signalling during Drosophila development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:32:58