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Titolo:
Antipsychotic drug treatment: recent advances
Autore:
Barnes, TRE; Joyce, EM;
Indirizzi:
Univ London Imperial Coll Sci Technol & Med, Sch Med, Div Neurosci & Psychol Med, London, England Univ London Imperial Coll Sci Technol & Med London England don, England
Titolo Testata:
CURRENT OPINION IN PSYCHIATRY
fascicolo: 1, volume: 14, anno: 2001,
pagine: 25 - 37
SICI:
0951-7367(200101)14:1<25:ADTRA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
TREATMENT-RESISTANT SCHIZOPHRENIA; RECEPTOR OCCUPANCY; NEUROLEPTIC DISCONTINUATION; CLOZAPINE DISCONTINUATION; PSYCHIATRIC-PATIENTS; WORKING-MEMORY; OLANZAPINE; RISPERIDONE; HALOPERIDOL; EFFICACY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
91
Recensione:
Indirizzi per estratti:
Indirizzo: Barnes, TRE Univ London Imperial Coll Sci Technol & Med, Ealing Hosp, Sch Med, Acad Ctr, St Bernards Wing, Ealing UB1 3EU, Middx, England Univ LondonImperial Coll Sci Technol & Med St Bernards Wing Ealing Middx England UB1 3EU
Citazione:
T.R.E. Barnes e E.M. Joyce, "Antipsychotic drug treatment: recent advances", CUR OPIN P, 14(1), 2001, pp. 25-37

Abstract

Most publications over the past year that are relevant to the topic of antipsychotic drug treatment were concerned with the newer, atypical antipsychotic drugs, and the present review reflects this emphasis. Accordingly, thelatest data on safety and efficacy are discussed for clozapine, risperidone, olanzapine, amisulpride, quetiapine and zotepine. The effects of the newantipsychotics on neurocognition have been a topic of interest for severalyears, but it has been difficult to draw firm conclusions from the diversestudies. Several useful reviews are now available, along with important and well controlled new studies. As discussed here, these advance our understanding in this area and support the opinion that the new antipsychotics have individual advantages over conventional drugs. Positron emission tomography and single-photon emission tomography ligand-binding studies of these drugs are also described, because they provide useful information linking dose, D-2-receptor occupancy and clinical response. A second emphasis of the review concerns the practicalities of treatment with both conventional and the newer antipsychotics. The latest information regarding the effects of abrupt discontinuation of antipsychotic medication and the treatment of refractory schizophrenia is appraised. Finally, the vexing question of how prolonged duration of untreated psychosis might adversely affect prognosis is considered in the light of several new papers, Curr Opin Psychiatry 14:25-37. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 04:17:38