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Titolo:
Effects of induced hypothermia on renal sympathetic nerve activity and baroreceptor reflex in urethane-anesthetized rabbits
Autore:
Xu, H; Aibiki, M; Seki, K; Ogura, S; Yokono, S; Ogli, K;
Indirizzi:
Kagawa Med Univ Hosp, Intens Care Unit, Kita Ku, Kagawa 7610793, Japan Kagawa Med Univ Hosp Kagawa Japan 7610793 Kita Ku, Kagawa 7610793, Japan
Titolo Testata:
CRITICAL CARE MEDICINE
fascicolo: 12, volume: 28, anno: 2000,
pagine: 3854 - 3860
SICI:
0090-3493(200012)28:12<3854:EOIHOR>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRAUMATIC BRAIN INJURY; HEART-RATE; MODERATE HYPOTHERMIA; CARDIOPULMONARY BYPASS; CIRCULATORY ARREST; CATECHOLAMINE; SYSTEM; VARIABILITY; RESPONSES; HUMANS;
Keywords:
arterial baroreceptors; autonomic nervous system; baroreflex sensitivity; catecholamines; induced hypothermia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Aibiki, M Kagawa Med Univ Hosp, Intens Care Unit, Kita Ku, 1750-1 Ikenobe,Kagawa 7610793, Japan Kagawa Med Univ Hosp 1750-1 Ikenobe Kagawa Japan 7610793 Japan
Citazione:
H. Xu et al., "Effects of induced hypothermia on renal sympathetic nerve activity and baroreceptor reflex in urethane-anesthetized rabbits", CRIT CARE M, 28(12), 2000, pp. 3854-3860

Abstract

Objective: To evaluate the role of the autonomic nervous system in hemodynamic changes during induced hypothermia. Design: Prospective, randomized animal study. Setting: An animal research laboratory in a medical university. Subjects: A total of 29 anesthetized rabbits. Interventions: Animals were anesthetized by intraperitoneal urethane. After tracheostomy and administration of gallamine, respiration was maintained by mechanical ventilatory support. The animals were divided into five groups (one control and the four experimental groups); animals were treated withan intact neuraxis and normothermia (control group), animals with an intact neuraxis (intact group), cervical vagotomized animals (vagotomy group), the carotid sinus and aortic nerves denervated animals (SAD group), and animals with SAD plus vagotomy (SADV group). The left renal sympathetic nerves were exposed by a retroperitoneal approach. Measurements and Main Results:We examined the effects of surface cooling on HR, mean arterial pressure, central venous pressure, and renal sympathetic nerve activity (RSNA) in the animals. Changes of baroreflex sensitivity and plasma catecholamines were also measured simultaneously. Surface coolingcaused progressive and profound decreases in DC in all experimental groups. In all groups, RSNAs increased at the early phase, which were followed byreturn to the precooling level. Conclusions: Hemodynamics and RSNA during induced hypothermia are regulated by mechanisms other than the baroreceptor reflex system, possibly the dermal cold receptors. Suppression of the baroreflex occurred on HR but not onRSNA during hypothermia, which may indicate direct effects of hypothermia on the heart. RSNA responses may be activated earlier than systemic catecholamine responses during induced hypothermia.

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Documento generato il 02/12/20 alle ore 14:46:33