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Titolo:
The importance of gene order in expression of the red and green visual pigment genes and in color vision
Autore:
Hayashi, T; Yamaguchi, T; Kitahara, K; Sharpe, LT; Jagle, H; Yamade, S; Ueyama, H; Motulsky, AG; Deeb, SS;
Indirizzi:
Univ Washington, Dept Genet, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 n, Dept Genet, Seattle, WA 98195 USA Univ Washington, Dept Med, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ton, Dept Med, Seattle, WA 98195 USA Jikei Univ, Sch Med, Dept Ophthalmol, Tokyo, Japan Jikei Univ Tokyo Japan kei Univ, Sch Med, Dept Ophthalmol, Tokyo, Japan Univ Tubingen, Augenklin, Abt 2, Forschungsstelle Expt Ophthalmol, D-7400 Tubingen, Germany Univ Tubingen Tubingen Germany D-7400 hthalmol, D-7400 Tubingen, Germany Shiga Univ Med Sci, Dept Ophthalmol, Shiga, Japan Shiga Univ Med Sci Shiga Japan v Med Sci, Dept Ophthalmol, Shiga, Japan
Titolo Testata:
COLOR RESEARCH AND APPLICATION
, volume: 26, anno: 2001, supplemento:, S
pagine: S79 - S83
SICI:
0361-2317(2001)26:<S79:TIOGOI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR-GENETICS; ARRAY; PHENOTYPE; LOCUS; XQ28; BLUE;
Keywords:
color vision; deutan; gene order; visual pigment mRNA; expression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Engineering, Computing & Technology
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Deeb, SS Univ Washington, Dept Genet, Box 357360, Seattle, WA 98195 USA Univ Washington Box 357360 Seattle WA USA 98195 tle, WA 98195 USA
Citazione:
T. Hayashi et al., "The importance of gene order in expression of the red and green visual pigment genes and in color vision", COL RES APP, 26, 2001, pp. S79-S83

Abstract

Deuteranomaly, and to a lesser extent deuteranopia, are associated with a 5' green-red 3' (G-R) visual pigment hybrid gene. Such G-R hybrid genes mayalso exist in males with normal color vision. This discrepancy can be explained if the position of the G-R hybrid gene in the at-ray determines the probability of ifs expression in the retina. In accord with our previous findings, we confirm that when a G-R hybrid gene occupies the second position in the array, a deutan defect results (N = 2); whereas when a normal green pigment gene does, normal color vision ensues (N 3). Regarding gene expression as a function of position in the army, in 5 postmortem retinae from individuals whose arrays contained one red and two green pigment genes that differed at a polymorphic site in exon 5, only the green pigment gene that occupied the second position in the array was expressed into retinal mRNA. Inconclusion, our data suggest that only the first two genes in the X-chromosome linked visual gene army are expressed in the retina and, therefore, influence the color vision phenotype. Green-red hybrid genes cause deuteranomaly only if they occupy the second position in the array. (C) 2000 John Wiley & Sons, Inc. Col Res Appl, 26, S79-S83, 2001.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/05/20 alle ore 08:10:01