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Titolo:
Effect of a single oral dose of moxifloxacin (400 mg and 800 mg) on ventricular repolarization in healthy subjects
Autore:
Demolis, JL; Kubitza, D; Tenneze, L; Funck-Brentano, C;
Indirizzi:
Univ Paris, Hop St Antoine, Dept Pharmacol, F-75012 Paris, France Univ Paris Paris France F-75012 e, Dept Pharmacol, F-75012 Paris, France Bayer Pharma, Inst Clin Pharmacol, Wuppertal, Germany Bayer Pharma Wuppertal Germany Inst Clin Pharmacol, Wuppertal, Germany Hop St Antoine, AP HP INSERM, Ctr Invest Clin, F-75571 Paris, France Hop St Antoine Paris France F-75571 r Invest Clin, F-75571 Paris, France
Titolo Testata:
CLINICAL PHARMACOLOGY & THERAPEUTICS
fascicolo: 6, volume: 68, anno: 2000,
pagine: 658 - 666
SICI:
0009-9236(200012)68:6<658:EOASOD>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
TORSADES-DE-POINTES; RECTIFIER POTASSIUM CURRENT; QT INTERVAL; CARDIAC REPOLARIZATION; RAPID COMPONENT; RATE DEPENDENCE; FEMALE GENDER; RISK FACTOR; PROLONGATION; ERYTHROMYCIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Funck-Brentano, C Univ Paris, Hop St Antoine, Dept Pharmacol, 184 Rue Faubourg St Antroine, F-75012 Paris, France Univ Paris 184 Rue Faubourg St Antroine Paris France F-75012
Citazione:
J.L. Demolis et al., "Effect of a single oral dose of moxifloxacin (400 mg and 800 mg) on ventricular repolarization in healthy subjects", CLIN PHARM, 68(6), 2000, pp. 658-666

Abstract

Background: Moxifloxacin is a ne iv fluoroquinolone, In vitro studies havesuggested that it could prolong ventricular repolarization, The main objective of this study was to measure the actual effect of single oral doses ofmoxifloxacin on QT interval duration in healthy volunteers,Methods: Nine men and 9 women participated in a double-blind, randomized, placebo-controlled, crossover study. Each participant received single oral doses (400 mg and 800 mg) of moxifloxacin or placebo. At the time of expected moxifloxacin maximum concentration, several electrocardiographic recordings were obtained at rest and during the course of a submaximal exercise test. QT interval and the corresponding RR interval value were measured within a wide range of RR intervals in each subject. Results: ANOVA showed that both moxifloxacin doses increased mean QT intervals compared with placebo. The mean QT interval duration at RR = 1000 ms was 379 +/- 24 ms during placebo, 394 +/- 33 ms during moxifloxacin 400 mg (P < .05), and 396 +/- 28 ms during moxifloxacin 800 mg (P < .05). Moxifloxacin-induced QT interval prolongation remained significant at all tested heart rates. The increase in QT interval duration relative to placebo remainedbetween 2.3% +/- 2.8% and 4.5% +/- 3.8% across the range of RR intervals tested. Conclusion: Moxifloxacin prolongs QT interval duration. The amplitude of this effect is small, and the risk of moxifloxacin-induced torsades de pointes is expected to be minimal when the drug is administered at the recommended dose of 400 mg/d, However, moxifloxacin should not be used in patients with predisposing factors of torsades de pointes such as electrolyte disturbances and bradycardia or during coadministration of proarrhythmic drugs.

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Documento generato il 04/04/20 alle ore 12:16:24