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Titolo:
Women's Healthy Lifestyle Project: A randomized clinical trial - Results at 54 months
Autore:
Kuller, LH; Simkin-Silverman, LR; Wing, RR; Meilahn, EN; Ives, DG;
Indirizzi:
Univ Pittsburgh, Dept Epidemiol, GSPH, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 l, GSPH, Pittsburgh, PA 15261 USA Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 sychiat, Pittsburgh, PA 15261 USA
Titolo Testata:
CIRCULATION
fascicolo: 1, volume: 103, anno: 2001,
pagine: 32 - 37
SICI:
0009-7322(20010102)103:1<32:WHLPAR>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREMENOPAUSAL WOMEN; RISK-FACTORS; PREVENTION; MENOPAUSE; CORONARY; DISEASE; PROFILE; WEIGHT; LIPIDS; FAT;
Keywords:
obesity; exercise; trials; lipoproteins; diet;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Kuller, LH Univ Pittsburgh, Dept Epidemiol, GSPH, 130 DeSoto St, Pittsburgh, PA 15261USA Univ Pittsburgh 130 DeSoto St Pittsburgh PA USA 15261 15261USA
Citazione:
L.H. Kuller et al., "Women's Healthy Lifestyle Project: A randomized clinical trial - Results at 54 months", CIRCULATION, 103(1), 2001, pp. 32-37

Abstract

Background-The Women's Healthy Lifestyle Project Clinical Trial tested thehypothesis that reducing saturated fat and cholesterol consumption and preventing weight gain by decreased caloric and fat intake and increased physical activity would prevent the rise in LDL cholesterol and weight gain in women during perimenopause to postmenopause. Methods and Results-There were 275 premenopausal women randomized into theassessment only group and 260 women into the intervention group. The mean age of participants at baseline was 47 years, and 92% of the women were white. The mean LDL cholesterol was 115 mg/dL at baseline, and mean body mass index was 25 kg/m(2). The follow-up through 54 months was excellent. By 54 months, 35% of the women had become postmenopausal. At the 54-month examination, there was a 3.5-mg/dL increase in LDL cholesterol in the interventiongroup and an 8.9-mg/dL increase in the assessment-only group (P=0.009). Weight decreased 0.2 lb in the intervention and increased 5.2 lb in the assessment-only group (P=0.000). Triglycerides and glucose also increased significantly more in the assessment-only group than in the intervention group. Waist circumference decreased 2.9 cm in the intervention compared with 0.5 cm in the assessment-only group (P=0.000). Conclusions-The trial was successful in reducing the rise in LDL cholesterol during perimenopause to postmenopause but could not completely eliminatethe rise in LDL. cholesterol. The trial was also successful in preventing the increase in weight from premenopause to perimenopause to postmenopause. The difference in LDL cholesterol between the assessment and intervention groups was most pronounced among postmenopausal women and occurred among hormone users and nonusers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 09:35:37