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Titolo:
Nerve sprouting and sympathetic hyperinnervation in a canine model of atrial fibrillation produced by prolonged right atrial pacing
Autore:
Chang, CM; Wu, TJ; Zhou, SM; Doshi, RN; Lee, MH; Ohara, T; Fishbein, MC; Karagueuzian, KS; Chen, PS; Chen, LS;
Indirizzi:
Cedars Sinai Med Ctr, Dept Med, Div Cardiol, Los Angeles, CA USA Cedars Sinai Med Ctr Los Angeles CA USA Div Cardiol, Los Angeles, CA USA Taichung Vet Gen Hosp, Taichung, Taiwan Taichung Vet Gen Hosp Taichung Taiwan ng Vet Gen Hosp, Taichung, Taiwan Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan Natl Yang Ming Univ Taipei Taiwan 112 Univ, Sch Med, Taipei 112, Taiwan Univ Calif Los Angeles, Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ So Calif, Keck Sch Med, Los Angeles, CA USA Univ So Calif Los Angeles CA USA alif, Keck Sch Med, Los Angeles, CA USA Childrens Hosp Los Angeles, Div Neurol 82, Los Angeles, CA 90027 USA Childrens Hosp Los Angeles Los Angeles CA USA 90027 Angeles, CA 90027 USA
Titolo Testata:
CIRCULATION
fascicolo: 1, volume: 103, anno: 2001,
pagine: 22 - 25
SICI:
0009-7322(20010102)103:1<22:NSASHI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
REFRACTORINESS; DISPERSION;
Keywords:
remodeling; electrophysiology; nervous system, autonomic; tachyarrhythmias; catecholamines;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Chen, LS Childrens Hosp Los Angeles, Div Neurol 82, 4650 Sunset Blvd, Los Angeles, CA 90027 USA Childrens Hosp Los Angeles 4650 Sunset Blvd Los Angeles CA USA 90027
Citazione:
C.M. Chang et al., "Nerve sprouting and sympathetic hyperinnervation in a canine model of atrial fibrillation produced by prolonged right atrial pacing", CIRCULATION, 103(1), 2001, pp. 22-25

Abstract

Background-Long-term rapid atrial pacing may result in atrial fibrillation(AF) in dogs. Whether there is histological evidence for neural remodelingis unclear. Method and Results-We performed rapid right atrial pacing in 6 dogs for 111+/-76 days to induce sustained AF. Tissues from 6 healthy dogs were used as controls. Immunocytochemical staining of cardiac nerves was performed using anti-growth-associated protein 43 (GAP43) and anti-tyrosine hydroxylase (TH) antibodies. In dogs with AF, the density of GAP43-positive and TH-positive nerves in the right atrium was 470+/-406 and 231+/-126 per mm(2), respectively, which was significantly (P<0.001) higher than the nerve density in control tissues (25+/-32 and 88+/-40 per mm(2), respectively). The density of GAP43-positive and TH-positive nerves in the atrial septum was 317+/-36 and 155+/-85 per mm(2), respectively, and was significantly (P<0.001) higher than the nerve density in control tissues (9+/-13 and 30+/-7 per mm(2),respectively). Similarly, the density of GAP43-positive and TH-positive nerves in the left atrium of dogs with AF was 119+/-61 and 91+/-40 per mm(2),respectively, which was significantly (P<0.001) higher than the nerve density in control tissues (10+/-15 and 38+/-39 per mm(2), respectively). Furthermore, in dogs with AF, the right atrium had a significantly higher nerve density than the left atrium. Microscopic examinations revealed an inhomogeneous distribution of cardiac nerves within each sampling site. Conclusions-Significant nerve sprouting and sympathetic hyperinnervation are present in a canine model of sustained AF produced by prolonged right atrial pacing. magnitude of nerve sprouting and hyperinnervation was higher in the right atrium than in the left atrium.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 17:39:44