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Titolo:
Plasticity of excitation and inhibition in the receptive field of primary auditory cortical neurons after limited receptor organ damage
Autore:
Rajan, R;
Indirizzi:
Monash Univ, Dept Physiol, Clayton, Vic 3800, Australia Monash Univ Clayton Vic Australia 3800 siol, Clayton, Vic 3800, Australia
Titolo Testata:
CEREBRAL CORTEX
fascicolo: 2, volume: 11, anno: 2001,
pagine: 171 - 182
SICI:
1047-3211(200102)11:2<171:POEAII>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY SOMATOSENSORY CORTEX; PRIMARY VISUAL-CORTEX; GLUTAMIC-ACID DECARBOXYLASE; PARTIAL DIGIT DENERVATION; PARTIAL COCHLEAR LESIONS; ADULT FLYING-FOX; INFERIOR COLLICULUS; STRIATE CORTEX; SENSORY DEAFFERENTATION; GABAERGIC INHIBITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
84
Recensione:
Indirizzi per estratti:
Indirizzo: Rajan, R Monash Univ, Dept Physiol, Clayton, Vic 3800, Australia Monash Univ Clayton Vic Australia 3800 yton, Vic 3800, Australia
Citazione:
R. Rajan, "Plasticity of excitation and inhibition in the receptive field of primary auditory cortical neurons after limited receptor organ damage", CEREB CORT, 11(2), 2001, pp. 171-182

Abstract

Permanent receptor organ damage can cause plasticity of topographic cortical maps of that receptor surface white temporary receptor organ damage, andconditions mimicking such damage, can unmask new excitatory inputs in central sensory neurons receiving input from that receptor surface. Cortical plasticity is associated with an anatomically or pharmacologically defined decrease in inhibition in cortex. It is therefore widely proposed that a reduction in central inhibition underlies cortical neural plasticity. Here I demonstrate that small receptor organ damage results, in primary auditory cortical (A1) neurons, in loss of one component of functionally defined afferent inhibition but unmasking of another component of afferent inhibition along with new excitatory responses. Overall, there did not appear to be any change in the strength of afferent inhibition or in the strength of excitation. Thus, auditory receptor organ damage can unmask new excitatory inputs as well as inhibitory inputs from within the receptive field of the neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 08:18:36