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Titolo:
Anatomical risk factors for phonological dyslexia
Autore:
Leonard, CM; Eckert, MA; Lombardino, LJ; Oakland, T; Kranzler, J; Mohr, CM; King, WM; Freeman, A;
Indirizzi:
Univ Florida, Inst Brain, Dept Neurosci, Gainesville, FL 32611 USA Univ Florida Gainesville FL USA 32611 Neurosci, Gainesville, FL 32611 USA Univ Florida, Inst Brain, Dept Commun Sci & Disorders, Gainesville, FL 32611 USA Univ Florida Gainesville FL USA 32611 isorders, Gainesville, FL 32611 USA Univ Florida, Inst Brain, Dept Educ Fdn, Gainesville, FL 32611 USA Univ Florida Gainesville FL USA 32611 Educ Fdn, Gainesville, FL 32611 USA
Titolo Testata:
CEREBRAL CORTEX
fascicolo: 2, volume: 11, anno: 2001,
pagine: 148 - 157
SICI:
1047-3211(200102)11:2<148:ARFFPD>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLANUM TEMPORALE ASYMMETRY; LANGUAGE IMPAIRMENT; BRAIN MORPHOLOGY; THYROID-HORMONE; SYLVIAN FISSURE; AUDITORY-CORTEX; WISC-III; SCHIZOPHRENIA; CHILDREN; INTELLIGENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Leonard, CM Univ Florida, Inst Brain, Dept Neurosci, POB 100244, Gainesville, FL 32611USA Univ Florida POB 100244 Gainesville FL USA 32611 , FL 32611USA
Citazione:
C.M. Leonard et al., "Anatomical risk factors for phonological dyslexia", CEREB CORT, 11(2), 2001, pp. 148-157

Abstract

Successful behavioral genetic studies require precise definition of a homogenous phenotype. This study searched for anatomical markers that might restrict variability in the reading disability phenotype. The subjects were 15college students (8 male/7 female) diagnosed with a reading disability (RD) and 15 controls (8 males/7 females). All subjects completed a cognitive and reading battery. Only 11 of the RD subjects had a phonological deficit [phonological dyslexia (PD): pseudo word decoding scores < 90 (27th percentile)]. Thirteen RD (9 PD) and 15 controls received a volumetric MRI scan. Four anatomical measures differentiated the PD group from the remainder of the subjects: (i) marked rightward cerebral asymmetry, (ii) marked leftward asymmetry of the anterior lobe of the cerebellum, (ii) combined leftward asymmetry of the planum and posterior ascending ramus of the sylvian fissure, and (iv) a large duplication of Heschl's gyrus on the left. When these fourmeasures were normalized and summed, the resulting variable predicted short- and long term phonological memory. By contrast, oral and written comprehension skills were predicted by a different anatomical variable: low cerebral volume. These findings provide neurobiological support for an RO phenotype characterized by phonological deficits in the presence of normal or superior comprehension. The study of individual variation in cortical structuremay provide a useful link between genotype and behavior.

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Documento generato il 25/01/20 alle ore 07:29:53