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Titolo:
Localization of glutamate receptors at a complex synapse - The mammalian photoreceptor synapse
Autore:
Brandstatter, JH; Hack, I;
Indirizzi:
Max Planck Inst Hirnforsch, Abt Neuroanat, D-60528 Frankfurt, Germany Max Planck Inst Hirnforsch Frankfurt Germany D-60528 Frankfurt, Germany
Titolo Testata:
CELL AND TISSUE RESEARCH
fascicolo: 1, volume: 303, anno: 2001,
pagine: 1 - 14
SICI:
0302-766X(200101)303:1<1:LOGRAA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ROD BIPOLAR CELLS; CENTRAL-NERVOUS-SYSTEM; AMINO-ACID RECEPTORS; OUTER PLEXIFORM LAYER; HIGH-AFFINITY KAINATE; SUBUNIT MESSENGER-RNAS; D-ASPARTATE RECEPTORS; RAT RETINA; NMDA-RECEPTOR; RABBIT RETINA;
Keywords:
ionotropic glutamate receptors; metabotropic glutamate receptors; cone pedicles; rod spherules; bipolar cells; horizontal cells; immunocytochemistry;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
123
Recensione:
Indirizzi per estratti:
Indirizzo: Brandstatter, JH Max Planck Inst Hirnforsch, Abt Neuroanat, Deutschordenstr 46, D-60528 Frankfurt, Germany Max Planck Inst Hirnforsch Deutschordenstr46 Frankfurt Germany D-60528
Citazione:
J.H. Brandstatter e I. Hack, "Localization of glutamate receptors at a complex synapse - The mammalian photoreceptor synapse", CELL TIS RE, 303(1), 2001, pp. 1-14

Abstract

A key feature of signal processing in the mammalian retina is parallel processing, where the segregation of visual information, e.g., brightness, darkness, and color, starts at the first synapse in the retina, the photoreceptor synapse. These various aspects are transmitted in parallel from the input neurons of the retina, the photoreceptor cells, through the interconnecting bipolar cells, to the output neurons, the ganglion cells. The photoreceptors and bipolar cells release a single excitatory neurotransmitter, glutamate, at their synapses. This parsimony is contrasted by the expression of a plethora of glutamate receptors, receptor subunits, and isoforms. The detailed knowledge of the synaptic distribution of glutamate receptors thus isof major importance in understanding the mechanisms of retinal signal processing. This review intends to highlight recent studies on the distributionof glutamate receptors at the photoreceptor synapses of the mammalian retina.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 01:37:11