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Titolo:
Preparation and performance of protein-adsorption-resistant asymmetric porous membrane composed of polysulfone/phospholipid polymer blend
Autore:
Hasegawa, T; Iwasaki, Y; Ishihara, K;
Indirizzi:
Univ Tokyo, Grad Sch Engn, Dept Mat Sci, Bunkyo Ku, Tokyo 1138656, Japan Univ Tokyo Tokyo Japan 1138656 Mat Sci, Bunkyo Ku, Tokyo 1138656, Japan Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Chiyoda Ku, Tokyo 1010062, Japan Tokyo Med & Dent Univ Tokyo Japan 1010062 iyoda Ku, Tokyo 1010062, Japan
Titolo Testata:
BIOMATERIALS
fascicolo: 3, volume: 22, anno: 2001,
pagine: 243 - 251
SICI:
0142-9612(200102)22:3<243:PAPOPA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOSPHOLIPID POLAR GROUPS; BLOOD COMPATIBILITY; 2-METHACRYLOYLOXYETHYL PHOSPHORYLCHOLINE; PLATELET-ADHESION; SIDE-CHAIN; SURFACE; HEMOCOMPATIBILITY; IMPROVEMENT; POLYSULFONE; COPOLYMERS;
Keywords:
hemodialysis; polysulfone; blood compatibility; 2-methacryloyloxyethyl phosphorylcholine; polymer blend; doubly functional polymer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Ishihara, K Univ Tokyo, Grad Sch Engn, Dept Mat Sci, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138656, Japan Univ Tokyo 7-3-1 Hongo Tokyo Japan 1138656 kyo 1138656, Japan
Citazione:
T. Hasegawa et al., "Preparation and performance of protein-adsorption-resistant asymmetric porous membrane composed of polysulfone/phospholipid polymer blend", BIOMATERIAL, 22(3), 2001, pp. 243-251

Abstract

To obtain protein-adsorption-resistant membrane for hemodialysis, we prepared a polymer blend composed of polysulfone and 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer (PSf/MPC polymer). The content of the MPC polymer in the PSf was 7 and 15 wt%. The asymmetric porous membrane was obtainedby the dry/wet membrane processing method. The surface characterization ofthe PSf/MPC polymer membrane by X-ray photoelectron spectroscopy revealed that the MPC polymer located at the surface. The mechanical strength of thePSf/MPC polymer membrane did not change compared with that of the PSf membrane. On the other hand, the permeability of solute below a molecular weight (Mw) of 2.0 x 10(4) through the PSf membrane increased with the addition of the MPC polymer, which is considered to be an effect of the hydrophilic character of the MPC polymer. The amount of protein adsorbed on the PSf membrane from plasma was reduced by the addition of the MPC polymer. The permeability of low-molecular-weight protein (Mw = 1.2 x 10(4)) did not change even after the PSf/MPC polymer membrane was contacted with plasma protein solution for 4 h, whereas it decreased dramatically in the case of the PSf membrane. Platelet adhesion was also effectively suppressed on the PSf/MPC polymer membrane. Based on these results, the MPC polymer could serve as a doubly functional polymeric additive, that is, to generate a protein-adsorption-resistant characteristic and to render the membrane hydrophilic. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:43:29