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Titolo:
Regulation of progesterone receptors and decidualization in uterine stromaof the estrogen receptor-alpha knockout mouse
Autore:
Kurita, T; Lee, KJ; Saunders, PTK; Cooke, PS; Taylor, JA; Lubahn, DB; Zhao, C; Makela, S; Gustafsson, JA; Dahiya, R; Cunha, GR;
Indirizzi:
Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Urol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Illinois, Dept Vet Biosci, Urbana, IL 61802 USA Univ Illinois UrbanaIL USA 61802 , Dept Vet Biosci, Urbana, IL 61802 USA MRC, Reprod Biol Unit, Edinburgh EH3 9ET, Midlothian, Scotland MRC Edinburgh Midlothian Scotland EH3 9ET h EH3 9ET, Midlothian, Scotland Univ Missouri, Dept Biochem, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 Dept Biochem, Columbia, MO 65211 USA Univ Missouri, Dept Child Hlth, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 pt Child Hlth, Columbia, MO 65211 USA Karolinska Inst, NOVUM, Dept Med Nutr & Biosci, S-14186 Huddinge, Sweden Karolinska Inst Huddinge Sweden S-14186 Biosci, S-14186 Huddinge, Sweden
Titolo Testata:
BIOLOGY OF REPRODUCTION
fascicolo: 1, volume: 64, anno: 2001,
pagine: 272 - 283
SICI:
0006-3363(200101)64:1<272:ROPRAD>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; RAT OVARY; ER-BETA; CHROMOSOMAL LOCALIZATION; TARGETED DISRUPTION; DEFICIENT MICE; FEMALE MOUSE; GENE; CLONING; CELLS;
Keywords:
decidua; estradiol; progesterone receptor; uterus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Cunha, GR Univ Calif San Francisco, Dept Anat, POB 0452, San Francisco, CA94143 USA Univ Calif San Francisco POB 0452 San Francisco CA USA 94143 USA
Citazione:
T. Kurita et al., "Regulation of progesterone receptors and decidualization in uterine stromaof the estrogen receptor-alpha knockout mouse", BIOL REPROD, 64(1), 2001, pp. 272-283

Abstract

Regulation of progesterone receptor (PR) in uterine stroma (endometrial stroma plus myometrium) by estrogen was investigated in estrogen receptor-alpha (ER alpha) knockout (alpha ERKO) mice. 17 beta -Estradiol (E-2) increased PR levels in uterine stroma of ovariectomized alpha ERKO mice, and ICI 182 780 (ICI) inhibited this E-2-induced PR expression. Estrogen receptor-beta (ERP) was detected in both uterine epithelium and stroma of wild-type andalpha ERKO mice by immunohistochemistry. In organ cultures of alpha ERKO uterus, both E-2 and diethylstilbestrol induced stromal PR, and ICI inhibited this induction. These findings suggest that estrogen induces stromal PR via ER beta in alpha ERKO uterus. However, this process is not mediated exclusively by ER beta, because in ER beta knockout mice, which express ER alpha, PR was up-regulated by E-2 in uterine stroma. In both wild-type and alpha ERKO mice, progesterone and mechanical traumatization were essential and sufficient to induce decidual cells, even though E-2 and ER alpha were alsorequired for increase in uterine weight. Progesterone receptor was strongly expressed in decidual cells in alpha ERKO mice, and ICI did not inhibit decidualization or PR expression. This study suggests that up-regulation of PR in endometrial stroma is mediated through at least three mechanisms: 1) classical estrogen signaling through ER alpha, 2) estrogen signaling through ER beta, and 3) as a result of mechanical stimulation plus progesterone, which induces stromal cells to differentiate into decidual cells. Each of these pathways can function independently of the others.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 18:10:46