Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Revelations of the RYK receptor
Autore:
Halford, MM; Stacker, SA;
Indirizzi:
Royal Melbourne Hosp, Ludwig Inst Canc Res, Melbourne, Vic 3050, AustraliaRoyal Melbourne Hosp Melbourne Vic Australia 3050 ne, Vic 3050, Australia Royal Melbourne Hosp, Cooperat Res Ctr Cellular Growth Factors, Melbourne,Vic 3050, Australia Royal Melbourne Hosp Melbourne Vic Australia 3050 rne,Vic 3050, Australia
Titolo Testata:
BIOESSAYS
fascicolo: 1, volume: 23, anno: 2001,
pagine: 34 - 45
SICI:
0265-9247(200101)23:1<34:ROTRR>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-TYROSINE KINASES; NEURONAL PATHWAY SELECTION; CENTRAL-NERVOUS-SYSTEM; SIGNAL-TRANSDUCTION; MOLECULAR-CLONING; CATALYTIC DOMAIN; H-RYK; CONSERVED FEATURES; COMMISSURAL AXONS; BINDING PROTEIN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
88
Recensione:
Indirizzi per estratti:
Indirizzo: Stacker, SA Royal Melbourne Hosp, Ludwig Inst Canc Res, POB 2008, Melbourne, Vic 3050,Australia Royal Melbourne Hosp POB 2008 Melbourne Vic Australia3050 lia
Citazione:
M.M. Halford e S.A. Stacker, "Revelations of the RYK receptor", BIOESSAYS, 23(1), 2001, pp. 34-45

Abstract

Significant progress has been made over the last decade in elucidating themechanisms employed by receptor protein tyrosine kinases (RTKs) in transducing extracellular signals critical for the regulation of diverse cellular activities. Nevertheless, revealing the biological significance of a subsetof the RTKs that contain catalytically inactive protein tyrosine kinase domains has proven more elusive. ErbB3 has served as the prototype for modelsof catalytically inactive RTK function, performing the role of signal diversification in heterodimeric receptor complexes with other ErbB subfamily members. The receptor related to tyrosine kinases (RYK) is unique amongst the catalytically inactive RTKs. Based on structural or functional propertiesof the extracellular domain, RYK cannot be classified into an existing RTKsubfamily. Recent genetic analyses of mouse Ryk and its Drosophila orthologue derailed have defined a role for this novel subfamily of receptors in the control of craniofacial development and neuronal pathway selection, respectively. Recent biochemical data lead us to propose a model that involves RYK in signal crosstalk and scaffold assembly with Eph receptors. This model is consistent with the established roles of Eph receptors and ephrins in craniofacial and nervous system morphogenesis. (C) 2001 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:11:24