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Titolo:
Reduction of latent inhibition by D-amphetamine in a conditioned suppression paradigm in humans
Autore:
Salgado, JV; Hetem, LA; Vidal, M; Graeff, FG; Danion, JM; Sandner, G;
Indirizzi:
INSERM, U405, F-67085 Strasbourg, France INSERM Strasbourg France F-67085 NSERM, U405, F-67085 Strasbourg, France Univ Sao Paulo, FFCLRP, Lab Neuropsicofarmacol, BR-14040901 Ribeirao Preto, Brazil Univ Sao Paulo Ribeirao Preto Brazil BR-14040901 BCibeirao Preto, Brazil Univ Sao Paulo, FMRP, Dept Neurol Psiquiatria & Psicol Med, BR-14040901 Ribeirao Preto, Brazil Univ Sao Paulo Ribeirao Preto Brazil BR-14040901 BCibeirao Preto, Brazil
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1-2, volume: 117, anno: 2000,
pagine: 61 - 67
SICI:
0166-4328(200012)117:1-2<61:ROLIBD>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRONE NORMAL SUBJECTS; HEALTHY PEOPLE; SCHIZOPHRENIA; HALOPERIDOL; DOPAMINE; PREEXPOSURE; MODEL; RATS; ABOLITION; SENSITIVITY;
Keywords:
amphetamine; conditioned suppression; latent inhibition; healthy volunteers; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Sandner, G INSERM, U405, 11 Rue Humann, F-67085 Strasbourg, France INSERM 11 Rue Humann Strasbourg France F-67085 asbourg, France
Citazione:
J.V. Salgado et al., "Reduction of latent inhibition by D-amphetamine in a conditioned suppression paradigm in humans", BEH BRA RES, 117(1-2), 2000, pp. 61-67

Abstract

The sensitivity of latent inhibition (LI) to amphetamine has been tested in humans with a paradigm close to the conditioned emotional response suppression currently used in experimental animals. The conditioned stimulus (CS)was a tone, the unconditioned stimulus (US) a strong white noise, and the response a transient delay in a regular sequence of hand movements in the resolution of the Tower of Toronto puzzle. The aim of this study was to verify whether the previously reported, disruptive effect of CS preexposure on conditioning really represents LI, by examining its sensitivity to amphetamine. Three groups of healthy volunteers received placebo, 5 or 10 mg of dexamphetamine sulphate, respectively, in a double-blind experimental design. The preexposure, conditioning and test phases were carried out under eitheramphetamine or placebo. The non preexposed groups treated with amphetaminewere not different from the non preexposed placebo group, indicating that amphetamine did not affect conditioning. Among the preexposed groups, thosereceiving 10 mg of amphetamine showed normal rates of conditioning, whereas those treated with either 5 mg of amphetamine or placebo showed LI. Similar results have been reported in experimental animals. This sensitivity to amphetamine suggests that the present paradigm may be used to study LI in humans. (C) 2000 Elsevier Science B.V. All rights reserved.

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Documento generato il 24/01/20 alle ore 15:46:34