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Titolo:
Associative learning and latent inhibition in a conditioned suppression paradigm in humans
Autore:
Salgado, JV; Vidal, M; Oberling, P; Graeff, FG; Danion, JM; Sandner, G;
Indirizzi:
INSERM, U405, F-67085 Strasbourg, France INSERM Strasbourg France F-67085 NSERM, U405, F-67085 Strasbourg, France Univ Sao Paulo, FFCLRP, Lab Neuropsicofarmacol, BR-14040901 Ribeirao Preto, Brazil Univ Sao Paulo Ribeirao Preto Brazil BR-14040901 BCibeirao Preto, Brazil Univ Sao Paulo, FMRP, Dept Neurol Psiquiatria & Psicol Med, BR-14040901 Ribeirao Preto, Brazil Univ Sao Paulo Ribeirao Preto Brazil BR-14040901 BCibeirao Preto, Brazil
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1-2, volume: 117, anno: 2000,
pagine: 53 - 60
SICI:
0166-4328(200012)117:1-2<53:ALALII>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMPHETAMINE-INDUCED DISRUPTION; PRONE NORMAL SUBJECTS; HEALTHY-VOLUNTEERS; SCHIZOPHRENIA; HALOPERIDOL; MODEL; RATS; PREEXPOSURE; ABOLITION; PEOPLE;
Keywords:
conditioned suppression; latent inhibition; healthy volunteers; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Sandner, G INSERM, U405, 1 Rue Humann, F-67085 Strasbourg, France INSERM 1Rue Humann Strasbourg France F-67085 rasbourg, France
Citazione:
J.V. Salgado et al., "Associative learning and latent inhibition in a conditioned suppression paradigm in humans", BEH BRA RES, 117(1-2), 2000, pp. 53-60

Abstract

A paradigm based on conditioned suppression of ongoing motor activity, sensitive to latent inhibition (LI), was developed and tested in healthy volunteers. Subjects were trained to move disks from one peg to another with a high degree of regularity in the Tower of Toronto puzzle, a well-known cognitive skill learning task. Once this was achieved, they were submitted to a Pavlovian conditioning procedure. The conditioned stimulus (CS) was a pure tone and the unconditioned stimulus (US) a loud white noise. The resulting response suppression was assessed by a transient increase in latency of thehand movements. In control subjects, there was non-contingent CS and US presentation. The results evidenced conditioning after a single CS-US pairing. Following five preexposures to the to-be-conditioned CS, however, conditioning was abolished, seemingly expressing LI. Because a weak unconditioned response to the tone was observed after its first two presentations, an additional experiment was performed with two preexposures to the to-be-conditioned CS. With such procedure, conditioning was obtained, supporting the existence of LI in the preceding experiment. These results indicate that the present paradigm may be useful for the study of LI in human subjects, havingthe advantage of being similar to the experimental conditions used in the majority of LI studies in experimental animals. (C) 2000 Elsevier Science B. V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:33:17