Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
A selective phosphodiesterase IV inhibitor, rolipram blocks both withdrawal behavioral manifestations, and c-Fos protein expression in morphine dependent mice
Autore:
Hamdy, MM; Mamiya, T; Noda, Y; Sayed, M; Assi, AA; Gomaa, A; Yamada, K; Nabeshima, T;
Indirizzi:
Nagoya Univ, Grad Sch Med, Dept Neuropsychopharmacol & Hosp Pharm, Showa Ku, Nagoya, Aichi 4668560, Japan Nagoya Univ Nagoya Aichi Japan 4668560 a Ku, Nagoya, Aichi 4668560, Japan Assiut Univ, Grad Sch Med, Dept Pharmacol, Assiut, Egypt Assiut Univ Assiut Egypt v, Grad Sch Med, Dept Pharmacol, Assiut, Egypt
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1, volume: 118, anno: 2001,
pagine: 85 - 93
SICI:
0166-4328(20010108)118:1<85:ASPIIR>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEMENT-BINDING PROTEIN; RAT LOCUS COERULEUS; ADENYLATE-CYCLASE; OPIATE WITHDRAWAL; BRAIN; CREB; PHOSPHORYLATION; CLONIDINE; NEURONS; ANTAGONISTS;
Keywords:
morphine dependence; rolipram; c-Fos expression; withdrawal manifestations; cAMP pathway; mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Nabeshima, T Nagoya Univ, Grad Sch Med, Dept Neuropsychopharmacol & Hosp Pharm, Showa Ku, 65 Tsuruma-cho, Nagoya, Aichi 4668560, Japan Nagoya Univ 65Tsuruma-cho Nagoya Aichi Japan 4668560 , Japan
Citazione:
M.M. Hamdy et al., "A selective phosphodiesterase IV inhibitor, rolipram blocks both withdrawal behavioral manifestations, and c-Fos protein expression in morphine dependent mice", BEH BRA RES, 118(1), 2001, pp. 85-93

Abstract

We investigated the effect of rolipram, a selective phosphodiesterase IV inhibitor, on morphine dependence in mice. The withdrawal manifestations were significantly reduced in mice that were treated with rolipram in combination with morphine repeatedly, compared to the mice treated with morphine and saline. Immunohistochemical study of c-Fos protein revealed a significantincrease in the protein expression, 1 h after naloxone induced withdrawal manifestations. A combination of rolipram and morphine treatment for 5 daysprevented the increase of c-Fos protein expression. Acute rolipram treatment prior to the naloxone challenge had no effect. Repeated treatment with rolipram itself had no effect either on behavior, or on c-Fos protein expression. These results suggest that chronic rolipram treatment in combination with morphine in mice will abolish the development of morphine dependence and the expression of c-Fos protein induced by naloxone challenge. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 09:57:28