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Titolo:
Neuropsychological profiles associated with subcortical white matter alterations and Parkinson's disease: Implications for the diagnosis of dementia
Autore:
Libon, DJ; Bogdanoff, B; Leopold, N; Hurka, R; Bonavita, J; Skalina, S; Swenson, R; Gitlin, HL;
Indirizzi:
Drexel Univ, Dept Psychiat, Neuropsychol Serv, Crozer Chest Med Ctr, Chester, PA 19013 USA Drexel Univ Chester PA USA 19013 zer Chest Med Ctr, Chester, PA 19013 USA Med Coll Penn & Hahnemann Univ, Upland, PA USA Med Coll Penn & Hahnemann Univ Upland PA USA nemann Univ, Upland, PA USA Merit Care Neurosci Ctr, Fargo, ND USA Merit Care Neurosci Ctr Fargo ND USA it Care Neurosci Ctr, Fargo, ND USA CUNY, New York, NY 10021 USA CUNY New York NY USA 10021CUNY, New York, NY 10021 USA
Titolo Testata:
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
fascicolo: 1, volume: 16, anno: 2001,
pagine: 19 - 32
SICI:
0887-6177(200101)16:1<19:NPAWSW>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIC VASCULAR DEMENTIA; ALZHEIMERS-DISEASE; HUNTINGTONS-DISEASE; APOLIPOPROTEIN-E; CLOCK DRAWINGS; MEMORY; CRITERIA; STATE; BRAIN; RISK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Libon, DJ Drexel Univ, Dept Psychiat, Neuropsychol Serv, Crozer Chest Med Ctr, Chester, PA 19013 USA Drexel Univ Chester PA USA 19013 Med Ctr, Chester, PA 19013 USA
Citazione:
D.J. Libon et al., "Neuropsychological profiles associated with subcortical white matter alterations and Parkinson's disease: Implications for the diagnosis of dementia", ARCH CLIN N, 16(1), 2001, pp. 19-32

Abstract

Despite the emergence of a number of new classification systems, the diagnosis of cerebrovascular dementia remains controversial. Also controversial is the significance of periventricular and deep white matter alterations (WMA) as seen on magnetic resonance imaging (MRI). To further clarify this issue, MRT scans were used to regroup patients clinically diagnosed with Alzheimer's disease (AD) or subcortical ischemic Vascular dementia (ND) into cohorts presenting with either little versus significant WMA on MRI, These two groups were then compared to demented patients diagnosed with idiopathic Parkinson's disease (PD) using a comprehensive neuropsychological protocol. Neuropsychological assessment failed to distinguish between patients with PD and significant WMA. By contrast, both of these patient groups exhibiteddisproportionate impairment on tests of executive systems functioning, whereas patients with little WMA showed greater impairment on tests of declarative memory and semantic knowledge. These findings constitute further evidence that the pattern of cognitive impairment associated with significant WMA is distinctly different when compared to AD. These results are discussed within the context of a growing body of literature suggesting that elementsof the underlying neuropathologies in AD and IVD are linked. Implications for the diagnosis of dementia are also discussed. (C) 2000 National Academyof Neuropsychology. Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 14:38:07